Nzegwu Nneka I, Mack Tim, DellaVentura Roseann, Dunphy Louise, Koval Nancy, Levit Orly, Bhandari Vineet
Department of Pediatrics, Section of Neonatal-Perinatal Medicine, Yale University School of Medicine , New Haven, CT , USA .
J Matern Fetal Neonatal Med. 2015 Apr;28(6):718-21. doi: 10.3109/14767058.2014.929659. Epub 2014 Jun 30.
To evaluate the clinical efficacy of the RAM nasal cannula (NC) with different modes of non-invasive ventilation (NIV) in the neonatal intensive care unit (NICU).
A single center prospective, observational study of infants placed on RAM NC. A small trial (Study 1) was completed in 16 infants on NIV via the RAM NC over a 48-h period to create Summary Statement recommendations. Next, over a 10-month period (Study 2), data were prospectively collected for the outcome of all infants receiving respiratory support with the RAM NC. Outcomes were compared between different modes of NIV and whether the recommendations were followed.
The Study 2 population consisted of 88 infants of whom 67 infants received nasal continuous positive airway pressure ventilation (NCPAP) and 21 received nasal intermittent positive pressure ventilation (NIPPV) via the RAM NC. The NIPPV group tended to be younger, smaller and stayed on the RAM NC longer. The overall success rate in weaning off the RAM NC, if our guidelines were followed, was 63%.
RAM NC use with NIV was well tolerated in the neonatal population with the use of our guidelines. We speculate that use of our guidelines will lead to a more systematic use of the RAM NC in the NICU.
评估在新生儿重症监护病房(NICU)中,不同模式无创通气(NIV)下RAM鼻导管(NC)的临床疗效。
对使用RAM NC的婴儿进行单中心前瞻性观察研究。一项小型试验(研究1)在16名通过RAM NC进行48小时无创通气的婴儿中完成,以制定总结声明建议。接下来,在10个月期间(研究2),前瞻性收集所有接受RAM NC呼吸支持婴儿的结局数据。比较不同无创通气模式之间的结局以及是否遵循了建议。
研究2的人群包括88名婴儿,其中67名婴儿通过RAM NC接受鼻持续气道正压通气(NCPAP),21名接受鼻间歇正压通气(NIPPV)。NIPPV组婴儿往往更年幼、更小,使用RAM NC的时间更长。如果遵循我们的指南,脱机RAM NC的总体成功率为63%。
在新生儿人群中,按照我们的指南使用RAM NC进行无创通气耐受性良好。我们推测,遵循我们的指南将使NICU中更系统地使用RAM NC。