Doležálková E, Unzeitig V
Ceska Gynekol. 2014 Apr;79(2):134-9.
Overview of neural tube defect in relation to use of folic acid among fertile-age women.
Review article.
Obstetrics and gynecology department OU and FN Ostrava.
Neural tube defects (NTDs) are one of the most common birth defects in the Czech Republic. The relation between using of folic acid and decrease of the incidence NTDs was first described in 1965. Fertile-age women are not able to get enough folate from their diet, therefore right timing and proper dosing of folic acid is the object of numerous studies. Many countries started theirs food fortification programs because of the high percentage of unplanned pregnancies and often low compliance.
The role of folic acid in prevention of NTDs is undeniable. Due to the large number of unplanned pregnancies long-term supplementation is recommended for all fertile-age women. If pregnancy is planned, the suplementation should begin at least one month before pregnancy. In both cases it is necessary to continue until the end of the week of 12. dosage should be individualized according to risk.
概述育龄妇女神经管缺陷与叶酸使用情况的关系。
综述文章。
俄斯特拉发大学医院和法尔肯医院妇产科。
神经管缺陷（NTDs）是捷克共和国最常见的出生缺陷之一。叶酸使用与神经管缺陷发病率降低之间的关系最早于1965年被描述。育龄妇女无法从饮食中获取足够的叶酸，因此叶酸的正确服用时间和合适剂量成为众多研究的对象。由于意外怀孕比例高且依从性往往较低，许多国家启动了食品强化计划。
叶酸在预防神经管缺陷中的作用不可否认。鉴于意外怀孕数量众多，建议所有育龄妇女长期补充叶酸。如果计划怀孕，补充应在怀孕前至少一个月开始。在这两种情况下，都必须持续到第12孕周结束。剂量应根据风险个体化。
