Department of Pharmacology and Toxicology, Virginia Commonwealth University, PO Box 980035, Massey Cancer Center 401 College St, Richmond, VA 23298, United States.
Biochem Pharmacol. 2014 Aug 1;90(3):208-11. doi: 10.1016/j.bcp.2014.05.016. Epub 2014 May 27.
Four different functional forms of autophagy have been observed to occur in tumor cells in response to chemotherapeutic drugs and radiation. Currently the different forms of autophagy are distinguished almost exclusively by determining the impact of autophagy inhibition on drug and radiation sensitivity. That is, it cannot otherwise be predicted whether the autophagy induced by radiation or chemotherapy is associated with resistance and the circumstances under which autophagy inhibition might be a useful strategy for enhancing sensitivity to therapy. This commentary highlights an additional level of complexity in the autophagy landscape, specifically that autophagy can switch its function even within the context of a specific external stress and/or a biological cancer model.
四种不同形式的自噬已被观察到在肿瘤细胞中发生，以响应化疗药物和辐射。目前，不同形式的自噬几乎完全通过确定自噬抑制对药物和辐射敏感性的影响来区分。也就是说，否则无法预测辐射或化疗引起的自噬是否与耐药性有关，以及在何种情况下自噬抑制可能是增强对治疗敏感性的有用策略。本评论强调了自噬景观中的另一个复杂性水平，具体来说，自噬甚至可以在特定的外部应激和/或生物癌症模型的背景下改变其功能。
