Naon Deborah, Scorrano Luca
Dulbecco-Telethon Institute, Venetian Institute of Molecular Medicine, Via Orus 2, 35129 Padua, Italy; Department of Biology, University of Padua, Via G. Colombo 3, 35121 Padua, Italy.
Dulbecco-Telethon Institute, Venetian Institute of Molecular Medicine, Via Orus 2, 35129 Padua, Italy; Department of Biology, University of Padua, Via G. Colombo 3, 35121 Padua, Italy.
Biochim Biophys Acta. 2014 Oct;1843(10):2184-94. doi: 10.1016/j.bbamcr.2014.05.011. Epub 2014 May 27.
The interface between mitochondria and the endoplasmic reticulum is emerging as a crucial hub for calcium signalling, apoptosis, autophagy and lipid biosynthesis, with far reaching implications in cell life and death and in the regulation of mitochondrial and endoplasmic reticulum function. Here we review our current knowledge on the structural and functional aspects of this interorganellar juxtaposition. This article is part of a Special Issue entitled: Calcium Signaling In Health and Disease. Guest Editors: Geert Bultynck, Jacques Haiech, Claus W. Heizmann, Joachim Krebs, and Marc Moreau.
线粒体与内质网之间的界面正逐渐成为钙信号传导、细胞凋亡、自噬和脂质生物合成的关键枢纽，对细胞生死以及线粒体和内质网功能的调节具有深远影响。在此，我们综述了关于这种细胞器间并列结构和功能方面的现有知识。本文是名为“健康与疾病中的钙信号传导”特刊的一部分。客座编辑：吉尔特·布尔廷克、雅克·艾歇、克劳斯·W·海兹曼、约阿希姆·克雷布斯和马克·莫罗。
