Stirban Alin
Profil Institut für Stoffwechselforschung GmbH, Neuss, Germany
J Diabetes Sci Technol. 2014 Jan;8(1):50-53. doi: 10.1177/1932296813514501. Epub 2014 Jan 1.
Many efforts have been made lately to develop cost-effective, simple, and reproducible tests for diabetes screening besides the already established fasting plasma glucose, the oral glucose tolerance test, and the glycated hemoglobin A1. Several tests have been proposed lately, based on the measurement of the so-called advanced glycation endproducts (AGEs). AGEs production is exacerbated during hyperglycemia, and their accumulation in different tissues reflects the degree and duration of dysglycemia. The human lens represents a tissue where AGEs accumulation can be particularly well assessed. The present article comments on the article by Cahn et al. published in this issue of the Journal of Diabetes Science and Technology. Cahn and coauthors tested a new scanning confocal biomicroscope for its accuracy to detect noninvasively subjects with diabetes or at risk for developing diabetes.
除了已有的空腹血糖、口服葡萄糖耐量试验和糖化血红蛋白A1之外，最近人们做出了许多努力来开发具有成本效益、简单且可重复的糖尿病筛查测试。最近有人提出了几种基于所谓的晚期糖基化终产物（AGEs）测量的测试方法。高血糖期间AGEs的产生会加剧，它们在不同组织中的积累反映了血糖异常的程度和持续时间。人晶状体是一个可以特别好地评估AGEs积累的组织。本文对Cahn等人发表在本期《糖尿病科学与技术杂志》上的文章进行了评论。Cahn及其合著者测试了一种新型扫描共聚焦生物显微镜检测糖尿病患者或有患糖尿病风险受试者的无创准确性。
