Lund C, Hansen O B, Kehlet H
Department of Anaesthesiology, Hvidovre University Hospital, Denmark.
Reg Anesth. 1989 Mar-Apr;14(2):72-7.
The effect of lumbar epidural analgesia with similar volumes (about 25 ml) of 0.25% and 0.5% bupivacaine on early (less than 0.5 seconds) somatosensory evoked potentials (SEPs) to electrical stimulation of the S1, L1, and T10 dermatomes was examined in two groups of ten patients. Level of sensory analgesia to pinprick was T5.7 +/- 0.8 and T6.4 +/- 0.7 in the 0.25% and 0.5% bupivacaine group, respectively. Motor blockade was more pronounced in the 0.5% bupivacaine group (p less than 0.05). Despite similar analgesia to pinprick, SEPs were more reduced during 0.5% bupivacaine than during 0.25%. These results support previous findings that quantitative assessment of neural blockade by SEP measurements may be more precise than pinprick analgesia.
在两组各10例患者中，研究了相似容量（约25毫升）的0.25%和0.5%布比卡因进行腰段硬膜外镇痛对电刺激S1、L1和T10皮节所产生的早期（小于0.5秒）体感诱发电位（SEP）的影响。0.25%和0.5%布比卡因组对针刺的感觉镇痛平面分别为T5.7±0.8和T6.4±0.7。0.5%布比卡因组的运动阻滞更明显（p<0.05）。尽管对针刺的镇痛效果相似，但0.5%布比卡因期间SEP的降低程度比0.25%布比卡因期间更大。这些结果支持了先前的研究发现，即通过SEP测量对神经阻滞进行定量评估可能比针刺镇痛更精确。
