Qu Li-Shuai, Zhou Guo-Xiong
Li-Shuai Qu, Guo-Xiong Zhou, Department of Gastroenterology, Affiliated Hospital of Nantong University, Nantong 226001, Jiangsu Province, China.
World J Gastroenterol. 2014 May 28;20(20):5999-6005. doi: 10.3748/wjg.v20.i20.5999.
Hepatitis B virus (HBV) infection remains a challenging global health problem, with more than 350 million people chronically infected and at risk of developing hepatocellular carcinoma (HCC). Interactions that occur among host, environmental, and viral factors determine the natural course and predict the prognosis of patients with chronic HBV infection. In the past decades, several important viral factors of predictive of HCC have been identified, such as high hepatitis B surface antigen level, seropositivity of hepatitis B e antigen, high viral load, viral genotype, and specific viral sequence mutations. Identification of certain viral risk factors for HCC development and stratification of patient risk are very important to perform future surveillance programs. In this article, we thus reviewed the risk of viral factors involved in hepatocarcinogenesis.
乙型肝炎病毒（HBV）感染仍然是一个具有挑战性的全球健康问题，超过3.5亿人被慢性感染并有发展为肝细胞癌（HCC）的风险。宿主、环境和病毒因素之间的相互作用决定了慢性HBV感染患者的自然病程并预测其预后。在过去几十年中，已经确定了几种预测HCC的重要病毒因素，如高乙肝表面抗原水平、乙肝e抗原血清阳性、高病毒载量、病毒基因型和特定病毒序列突变。识别HCC发生的某些病毒风险因素以及对患者风险进行分层对于开展未来的监测计划非常重要。因此，在本文中，我们综述了参与肝癌发生的病毒因素的风险。
