Ferry Béatrice, Gavris Mirela, Tifrea Corina, Serbanoiu Sorin, Pop Anca-Cristina, Bembea Marius, Courteix Daniel
Clermont Université, Université Blaise Pascal, EA 3533, Laboratoire des Adaptations Métaboliques à l'Exercice en Conditions Physiologiques et Pathologiques, Clermont-Ferrand, France; Université Limoges, Faculté des Sciences et Techniques, STAPS, Limoges, France.
UNEFS Bucarest, Centre de Recherche Interdisciplinaire "Dr. Alexandru Partheniu", Romania.
Res Dev Disabil. 2014 Sep;35(9):2077-84. doi: 10.1016/j.ridd.2014.05.004. Epub 2014 May 28.
The systemic complications of Down syndrome (DS) attenuate the osteogenic response to physical activity in DS patients. Through an interventional study we showed the effects of physical training on development of bone mineral content (BMC) and density (BMD) as well as on quantitative bone ultrasound (QUS) parameters in individuals with DS. A total of 42 children with DS were randomly assigned to either an exercising (DS-E, n=20, age 16 ± 1.8 years) or non-exercising group (DS-NE, n=22, age 16.9 ± 1.5 years). DS-E group was assigned to a program of osteogenic activities with 60 min sessions twice a week, over 12 month period. Bone mass measures were performed by dual X-ray absorpsiometry (DXA) at the spine and hip, and ultrasound attenuation (BUA) and velocity (SOS) assessed from the calcaneus by QUS device. All bone parameters had evolved with age, except for neck BMD. One year of training increased BMC values at lumbar spine (7%, p<.005) and total hip (10%, p<.05), and BMD values only at lumbar spine (4%, p<.05). Changes in BUA and SOS values were not evident following training. Trained individuals increased their motor skills measured through Eurofit tests. It was concluded that a program of osteogenic physical training may induce bone improvement in children with DS, but with a lower magnitude than that reported in the specialized literature for individuals without DS.
唐氏综合征（DS）的全身并发症会减弱DS患者对体育活动的成骨反应。通过一项干预性研究，我们展示了体育锻炼对DS个体骨矿物质含量（BMC）和密度（BMD）的发展以及定量骨超声（QUS）参数的影响。共有42名DS儿童被随机分为运动组（DS-E，n = 20，年龄16±1.8岁）或非运动组（DS-NE，n = 22，年龄16.9±1.5岁）。DS-E组被安排参加一项成骨活动计划，每周两次，每次60分钟，为期12个月。通过双能X线吸收法（DXA）测量脊柱和髋部的骨量，并用QUS设备从跟骨评估超声衰减（BUA）和速度（SOS）。除了颈部BMD外，所有骨参数均随年龄增长而变化。一年的训练使腰椎的BMC值增加了7%（p <.005），全髋的BMC值增加了10%（p <.05），仅腰椎的BMD值增加了4%（p <.05）。训练后BUA和SOS值的变化不明显。通过欧洲体质测试（Eurofit）测量，接受训练的个体运动技能有所提高。研究得出结论，成骨体育训练计划可能会使DS儿童的骨骼得到改善，但改善程度低于专业文献中报道的非DS个体。
