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β-地中海贫血伴脾切除患者接种 23 价肺炎球菌多糖疫苗后，13 价肺炎球菌结合疫苗的抗原特异性 B 细胞应答。

Antigen-specific B-cell response to 13-valent pneumococcal conjugate vaccine in asplenic individuals with β-thalassemia previously immunized with 23-valent pneumococcal polysaccharide vaccine.

机构信息

Infectious Diseases Unit, First Department of Paediatrics, Aghia Sofia Children's Hospital.

Department of Biological Chemistry, Medical School.

出版信息

Clin Infect Dis. 2014 Sep 15;59(6):862-5. doi: 10.1093/cid/ciu409. Epub 2014 May 30.

DOI:10.1093/cid/ciu409
PMID:24879786
Abstract

Current guidelines recommend a combined schedule of a 13-valent pneumococcal conjugate vaccine (PCV13) and PPSV23 (23-valent polysaccharide vaccine) for asplenic individuals. We show that PCV13 induces a T-dependent immune response in asplenic individuals with β-thalassemia, but previous PPSV23s affect the memory B-cell response in a dose- and time-dependent manner. Clinical Trials Registration. NCT01846923.

摘要

现行指南建议对脾切除个体同时使用 13 价肺炎球菌结合疫苗（PCV13）和 PPSV23（23 价多糖疫苗）。我们发现 PCV13 可诱导β-地中海贫血脾切除个体产生 T 细胞依赖性免疫应答，但既往 PPSV23 会以剂量和时间依赖的方式影响记忆 B 细胞应答。临床试验注册。NCT01846923。

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