Sindel B D, Maisels M J, Ballantine T V
Division of Newborn Medicine, Milton S. Hershey Medical Center, Pennsylvania State University College of Medicine, Hershey.
Am J Dis Child. 1989 Sep;143(9):1103-6. doi: 10.1001/archpedi.1989.02150210139034.
Recurrent aspiration after gastroesophageal reflux (GER) may contribute to the severity of chronic lung disease. If so, it should be possible to document acid reflux to the proximal esophagus. Using an esophageal pH probe placed at the level of the first or second thoracic vertebra, we evaluated GER in 14 infants with bronchopulmonary dysplasia (BPD) and 13 infants without BPD. The infants with BPD had significantly less GER, as measured by the percentage of time the pH was less than 4 (3.26% +/- 7.05% vs 12.88% +/- 15.27% [mean +/- SD]), number of GER episodes per hour (0.46 +/- 0.66 vs 1.35 +/- 0.83), number of GER episodes lasting longer than 5 minutes per hour (0.10 +/- 0.23 vs 0.31 +/- 0.29), and longest GER episode (6.76 +/- 10.29 vs 26.66 +/- 38.30 minutes). Gastroesophageal reflux may be unimportant in infants with BPD, or even occasional episodes of GER may aggravate existing lung disease.
胃食管反流（GER）后的反复误吸可能会加重慢性肺部疾病的严重程度。如果是这样，应该能够记录到酸反流至食管近端的情况。我们使用置于第一或第二胸椎水平的食管pH探头，对14例患有支气管肺发育不良（BPD）的婴儿和13例无BPD的婴儿进行了GER评估。通过pH小于4的时间百分比（3.26%±7.05%对12.88%±15.27%[平均值±标准差]）、每小时GER发作次数（0.46±0.66对1.35±0.83）、每小时持续超过5分钟的GER发作次数（0.10±0.23对0.31±0.29）以及最长GER发作时间（6.76±10.29对26.66±38.30分钟）来衡量，患有BPD的婴儿GER明显较少。胃食管反流在患有BPD的婴儿中可能并不重要，或者即使偶尔的GER发作也可能加重现有的肺部疾病。
