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本文引用的文献

1
Is there justification for prophylactic extraction of third molars? A systematic review.预防性拔除第三磨牙是否合理？系统评价。
Braz Oral Res. 2013 Mar-Apr;27(2):183-8.
2
Efficacy of amoxicillin treatment in preventing postoperative complications in patients undergoing third molar surgery: a prospective, randomized, double-blind controlled study.阿莫西林治疗对预防第三磨牙手术患者术后并发症的疗效：一项前瞻性、随机、双盲对照研究。
J Oral Maxillofac Surg. 2011 Jun;69(6):e5-14. doi: 10.1016/j.joms.2011.01.019. Epub 2011 Apr 5.
3
Antibiotic prophylaxis in third molar surgery: A randomized double-blind placebo-controlled clinical trial using split-mouth technique.第三磨牙手术中的抗生素预防：一项采用分口技术的随机双盲安慰剂对照临床试验。
Int J Oral Maxillofac Surg. 2010 Feb;39(2):107-14. doi: 10.1016/j.ijom.2009.12.014. Epub 2010 Feb 1.
4
Effectiveness of antibiotic prophylaxis in third molar surgery: a meta-analysis of randomized controlled clinical trials.第三磨牙手术中抗生素预防性用药的有效性：一项随机对照临床试验的荟萃分析
J Oral Maxillofac Surg. 2007 Oct;65(10):1909-21. doi: 10.1016/j.joms.2007.03.004.
5
Antibiotic use in dental practice. A review.牙科实践中的抗生素使用。一篇综述。
Med Oral Patol Oral Cir Bucal. 2007 May 1;12(3):E186-92.
6
Adverse drug reactions related to amoxicillin alone and in association with clavulanic acid: data from spontaneous reporting in Italy.单独使用阿莫西林以及与克拉维酸联合使用时的药物不良反应：来自意大利自发报告的数据。
J Antimicrob Chemother. 2007 Jul;60(1):121-6. doi: 10.1093/jac/dkm111. Epub 2007 Apr 21.
7
Does prophylactic administration of systemic antibiotics prevent postoperative inflammatory complications after third molar surgery?预防性全身应用抗生素能否预防第三磨牙手术后的炎症性并发症？
J Oral Maxillofac Surg. 2007 Feb;65(2):177-85. doi: 10.1016/j.joms.2006.10.016.
8
Prophylaxis versus pre-emptive treatment for infective and inflammatory complications of surgical third molar removal: a randomized, double-blind, placebo-controlled, clinical trial with sustained release amoxicillin/clavulanic acid (1000/62.5 mg).预防性治疗与抢先治疗对第三磨牙拔除术后感染性和炎性并发症的影响：一项采用缓释阿莫西林/克拉维酸（1000/62.5毫克）的随机、双盲、安慰剂对照临床试验
Int J Oral Maxillofac Surg. 2007 Apr;36(4):321-7. doi: 10.1016/j.ijom.2006.11.007. Epub 2007 Jan 16.
9
Routine antibiotic prophylaxis is not necessary during operations to remove third molars.拔除第三磨牙的手术过程中无需常规预防性使用抗生素。
Br J Oral Maxillofac Surg. 2008 Mar;46(2):133-5. doi: 10.1016/j.bjoms.2006.11.005. Epub 2006 Dec 22.
10
Antibiotic susceptibility of the bacteria causing odontogenic infections.引起牙源性感染的细菌的抗生素敏感性。
Med Oral Patol Oral Cir Bucal. 2006 Jan 1;11(1):E70-5.

阿莫西林与阿莫西林克拉维酸盐在拔除第三磨牙中的对比试验。

Comparative trial between the use of amoxicillin and amoxicillin clavulanate in the removal of third molars.

作者信息

Iglesias-Martín Fernando, García-Perla-García Alberto, Yañez-Vico Rosa, Aced-Jiménez Elena, Arjona-Gerveno Esther, González-Padilla Juan-David, Gutierrez-Pérez Jose-Luis, Torres-Lagares Daniel

机构信息

Facultad de Odontología de Sevilla, C/ Avicena s/n 41009, Sevilla (SPAIN),

出版信息

Med Oral Patol Oral Cir Bucal. 2014 Nov 1;19(6):e612-5. doi: 10.4317/medoral.19778.

DOI:10.4317/medoral.19778
PMID:24880449
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4259379/
Abstract

OBJECTIVE

The purpose of this study was to compare the use of amoxicillin (1g) vs amoxicillin and clavulanate (875/125mg) after extraction of retained third molars for prevention of infectious complications.

STUDY DESIGN

The study involved 546 patients attending for removal a retained third molar and divided in to two groups: Group 1 - amoxicillin and clavunate (875/125mg) group (n=257) and Group 2 - amoxicillin (1g) group (n=289). All patients were recalled for investigating the possibility of infection, presence of diarrhea and further analgesic intake.

RESULTS

From a total of 546 patients, the frequency of infection was 1.4%, without no statistically differences between the two groups. Group 1 showed statistically higher presence of patients with gastrointestinal complications (p>0.05). In 546 patients, 2.7% of patients reported severe pain that would not relieve with medication.

CONCLUSION

The results of our study show that the use of amoxicillin (1g) and amoxicillin and clavunate (875/125mg) is similar efficacious in preventing infection after retained third molar extraction but amoxicillin and clavunate (875/125mg) produces more gastrointestinal discomfort.

摘要

目的

本研究旨在比较拔除阻生第三磨牙后使用阿莫西林（1g）与阿莫西林克拉维酸钾（875/125mg）预防感染并发症的效果。

研究设计

该研究纳入了546例前来拔除阻生第三磨牙的患者，分为两组：第1组为阿莫西林克拉维酸钾（875/125mg）组（n = 257），第2组为阿莫西林（1g）组（n = 289）。所有患者均被召回，以调查感染可能性、腹泻情况及进一步的止痛药物服用情况。

结果

在总共546例患者中，感染发生率为1.4%，两组之间无统计学差异。第1组胃肠道并发症患者的发生率在统计学上更高（p>0.05）。在546例患者中，2.7%的患者报告有严重疼痛，药物无法缓解。

结论

我们的研究结果表明，拔除阻生第三磨牙后，使用阿莫西林（1g）和阿莫西林克拉维酸钾（875/125mg）预防感染的效果相似，但阿莫西林克拉维酸钾（875/125mg）会导致更多胃肠道不适。