阿莫西林与阿莫西林克拉维酸盐在拔除第三磨牙中的对比试验。
Comparative trial between the use of amoxicillin and amoxicillin clavulanate in the removal of third molars.
作者信息
Iglesias-Martín Fernando, García-Perla-García Alberto, Yañez-Vico Rosa, Aced-Jiménez Elena, Arjona-Gerveno Esther, González-Padilla Juan-David, Gutierrez-Pérez Jose-Luis, Torres-Lagares Daniel
机构信息
Facultad de Odontología de Sevilla, C/ Avicena s/n 41009, Sevilla (SPAIN),
出版信息
Med Oral Patol Oral Cir Bucal. 2014 Nov 1;19(6):e612-5. doi: 10.4317/medoral.19778.
Abstract
OBJECTIVE
The purpose of this study was to compare the use of amoxicillin (1g) vs amoxicillin and clavulanate (875/125mg) after extraction of retained third molars for prevention of infectious complications.
STUDY DESIGN
The study involved 546 patients attending for removal a retained third molar and divided in to two groups: Group 1 - amoxicillin and clavunate (875/125mg) group (n=257) and Group 2 - amoxicillin (1g) group (n=289). All patients were recalled for investigating the possibility of infection, presence of diarrhea and further analgesic intake.
RESULTS
From a total of 546 patients, the frequency of infection was 1.4%, without no statistically differences between the two groups. Group 1 showed statistically higher presence of patients with gastrointestinal complications (p>0.05). In 546 patients, 2.7% of patients reported severe pain that would not relieve with medication.
CONCLUSION
The results of our study show that the use of amoxicillin (1g) and amoxicillin and clavunate (875/125mg) is similar efficacious in preventing infection after retained third molar extraction but amoxicillin and clavunate (875/125mg) produces more gastrointestinal discomfort.
摘要
目的
本研究旨在比较拔除阻生第三磨牙后使用阿莫西林（1g）与阿莫西林克拉维酸钾（875/125mg）预防感染并发症的效果。
研究设计
该研究纳入了546例前来拔除阻生第三磨牙的患者，分为两组：第1组为阿莫西林克拉维酸钾（875/125mg）组（n = 257），第2组为阿莫西林（1g）组（n = 289）。所有患者均被召回，以调查感染可能性、腹泻情况及进一步的止痛药物服用情况。
结果
在总共546例患者中，感染发生率为1.4%，两组之间无统计学差异。第1组胃肠道并发症患者的发生率在统计学上更高（p>0.05）。在546例患者中，2.7%的患者报告有严重疼痛，药物无法缓解。
结论
我们的研究结果表明，拔除阻生第三磨牙后，使用阿莫西林（1g）和阿莫西林克拉维酸钾（875/125mg）预防感染的效果相似，但阿莫西林克拉维酸钾（875/125mg）会导致更多胃肠道不适。
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