Department of Kinesiology and Physical Education, University of Lethbridge, Lethrbidge, AB, Canada; Mary Emily Clinical Nutrition Research Unit, School of Dietetics and Human Nutrition, McGill University, Ste-Anne-de-Bellevue, QC, Canada.
Mary Emily Clinical Nutrition Research Unit, School of Dietetics and Human Nutrition, McGill University, Ste-Anne-de-Bellevue, QC, Canada.
J Clin Densitom. 2015 Jan-Mar;18(1):60-7. doi: 10.1016/j.jocd.2014.04.121. Epub 2014 May 28.
This study examined the associations between vitamin D status, bone mineral content (BMC), areal bone mineral density (aBMD), and markers of calcium homeostasis in preschool-aged children. Children (n=488; age range: 1.8-6.0 y) were randomly recruited from Montreal. The distal forearm was scanned using a peripheral dual-energy X-ray absorptiometry scanner (Lunar PIXI; GE Healthcare, Fairfield, CT). A subset (n=81) had clinical dual-energy X-ray absorptiometry (cDXA) scans (Hologic 4500A Discovery Series) of lumbar spine (LS) 1-4, whole body, and ultradistal forearm. All were assessed for plasma 25-hydroxyvitamin D [25(OH)D] and parathyroid hormone concentrations (Liaison; Diasorin), ionized calcium (ABL80 FLEX; Radiometer Medical A/S), and dietary vitamin D and calcium intakes by survey. Age (p<0.001) and weight-for-age Z-score (p<0.001) were positively associated with BMC and aBMD in all regression models, whereas male sex contributed positively to forearm BMC and aBMD. Having a 25(OH)D concentration of >75 nmol/L positively associated with forearm and whole body BMC and aBMD (p<0.036). Sun index related to (p<0.029) cDXA forearm and LS 1-4 BMC and whole-body aBMD. Nutrient intakes did not relate to BMC or aBMD. In conclusion, higher vitamin D status is linked to higher BMC and aBMD of forearm and whole body in preschool-aged children.
本研究旨在探讨学龄前儿童维生素 D 状况、骨矿物质含量（BMC）、骨矿物质密度（aBMD）和钙稳态标志物之间的关系。从蒙特利尔随机招募了 488 名儿童（年龄范围：1.8-6.0 岁）。使用外周双能 X 射线吸收仪（Lunar PIXI；GE Healthcare，Fairfield，CT）扫描远端前臂。从所有儿童中抽取了 81 名（n=81）进行临床双能 X 射线吸收仪（cDXA）扫描（Hologic 4500A Discovery Series），扫描部位包括腰椎（LS）1-4、全身和超远端前臂。所有儿童均进行了血浆 25-羟维生素 D [25(OH)D]和甲状旁腺激素浓度（Liaison；Diasorin）、离子钙（ABL80 FLEX；Radiometer Medical A/S）的检测，并通过问卷调查评估了饮食中维生素 D 和钙的摄入量。在所有回归模型中，年龄（p<0.001）和体重年龄 Z 评分（p<0.001）与 BMC 和 aBMD 呈正相关，而男性性别则对前臂 BMC 和 aBMD 有正向贡献。25(OH)D 浓度>75 nmol/L 与前臂和全身 BMC 和 aBMD 呈正相关（p<0.036）。太阳指数与 cDXA 前臂和 LS 1-4 BMC 和全身 aBMD 呈相关关系（p<0.029）。营养素摄入量与 BMC 或 aBMD 无关。总之，较高的维生素 D 状态与学龄前儿童前臂和全身 BMC 和 aBMD 较高相关。
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