Children's Health and Exercise Research Centre, University of Exeter, Exeter, UK.
Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland.
Osteoporos Int. 2021 Aug;32(8):1609-1620. doi: 10.1007/s00198-021-05872-z. Epub 2021 Feb 5.
It is unclear how physical activity intensity and vitamin D status are related to bone health in prepubertal children. We found positive associations between vitamin D status and moderate-to-vigorous physical activity with bone in boys and girls. This highlights the importance of lifestyle factors for skeletal health prepuberty.
The sex-specific independent and interactive associations of physical activity (PA) intensity and serum 25-hydroxyvitamin D (25(OH)D) levels with areal bone mineral density (aBMD) were investigated in prepubertal children.
The participants were 366 prepubertal Finnish children (190 boys, 176 girls) aged 6-8 years. Linear regression analysed the associations of sedentary time (ST), light PA (LPA), moderate PA (MPA), moderate-to-vigorous PA (MVPA) and vigorous PA (VPA) measured by accelerometery, and serum 25(OH)D with total body less head (TBLH) and lower-limb aBMD, measured by dual-energy X-ray absorptiometry.
There was no interaction between PA intensity or serum 25(OH)D and sex with aBMD. MPA and MVPA were positively associated with TBLH and lower-limb aBMD (β = 0.11, 95% CI 0.02-0.20, p = 0.01). Serum 25(OH)D was positively associated with TBLH and lower-limb aBMD (β = 0.09, 95% CI 0.01-0.18, p = 0.03). There were no interactions between PA intensity and serum 25(OH)D with aBMD.
Vitamin D status, MPA and MVPA levels in active prepubertal children were positively associated with aBMD. The influence of MVPA is due to the MPA component, though our findings regarding the role of VPA should be interpreted with caution, as shorter accelerometer epochs are needed to more accurately assess VPA. This study adds evidence to the promotion of MPA and behaviours to encourage optimal vitamin D status in supporting skeletal health in childhood, though these need not be used in conjunction to be beneficial, and a sex-specific approach is not necessary in prepubertal children.
NCT01803776 . Date of registration: 4/03/2013.
目前尚不清楚体力活动强度和维生素 D 状况与青春期前儿童的骨骼健康有何关系。我们发现维生素 D 状况与中高强度体力活动与男孩和女孩的骨骼呈正相关。这凸显了生活方式因素对青春期前骨骼健康的重要性。
本研究旨在探讨体力活动（PA）强度和血清 25-羟维生素 D（25（OH）D）水平与青春期前儿童的骨矿物质密度（aBMD）的独立和交互关系。
参与者为 366 名芬兰青春期前儿童（男 190 名，女 176 名），年龄为 6-8 岁。线性回归分析了加速度计测量的久坐时间（ST）、轻度 PA（LPA）、中度 PA（MPA）、中高强度 PA（MVPA）和高强度 PA（VPA）与通过双能 X 射线吸收法测量的总身体减去头部（TBLH）和下肢 aBMD 之间的关系。
PA 强度或血清 25（OH）D 与性别与 aBMD 之间无交互作用。MPA 和 MVPA 与 TBLH 和下肢 aBMD 呈正相关（β=0.11，95%CI 0.02-0.20，p=0.01）。血清 25（OH）D 与 TBLH 和下肢 aBMD 呈正相关（β=0.09，95%CI 0.01-0.18，p=0.03）。PA 强度与血清 25（OH）D 与 aBMD 之间无交互作用。
在活跃的青春期前儿童中，维生素 D 状态、MPA 和 MVPA 水平与 aBMD 呈正相关。MVPA 的影响归因于 MPA 成分，尽管我们关于 VPA 作用的研究结果应谨慎解释，因为需要使用更短的加速度计时间来更准确地评估 VPA。本研究为促进中高强度 PA 和促进维生素 D 状态达到最佳水平以支持儿童骨骼健康提供了证据，尽管这些方法不必同时使用才有好处，而且在青春期前儿童中不需要采用性别特异性方法。
NCT01803776。注册日期：2013 年 4 月 3 日。
