Hauksson Haukur Heidar, Hrafnkelsson Hannes, Magnusson Kristjan Thor, Johannsson Erlingur, Sigurdsson Emil L
Solvangur Health Care Center, Hafnarfjordur, Iceland.
Seltjarnarnes Health Care Center, Seltjarnarnes, Iceland.
J Bone Miner Metab. 2016 Sep;34(5):580-6. doi: 10.1007/s00774-015-0704-0. Epub 2015 Jul 29.
The importance of vitamin D for children's bone health has been well established, but the effects of less severe deficiency are not fully known. The main objective of this study was to assess the vitamin D status of Icelandic children at the age of 7, and again at 9 years of age, and the association of vitamin D status with bone mineral content and bone accrual over 2 years. We invited 321 children to participate in this study, and 267 (83 %) took part; 211 (79 %) underwent a DXA scan and 164 were again scanned 2 years later; 159 (60 %) vitamin D samples were measured and 119 (75 %) were measured again 2 years later. At age 7, 65 % of the children had vitamin D concentrations <50 nmol/l, and at age 9 this figure was 60 %. At age 7, 43 % of the children had insufficient amounts of vitamin D (37.5-50 nmol/l), and 22 % had a vitamin D deficiency (<37.5 nmol/l). In linear regression analysis, no association was found between vitamin D and bone mineral content. Furthermore, there was no significant difference in bone accrual over 2 years for the children with insufficient or deficient vitamin D at both ages, compared to those having more than 50 nmol/l at both time points. More than 60 % of Icelandic children have inadequate concentrations of vitamin D in serum repeatedly over a 2-year interval. However, vitamin D in the range did not have a significant effect on bone mineral content or accrual at ages 7 and 9.
维生素D对儿童骨骼健康的重要性已得到充分证实，但不太严重的维生素D缺乏的影响尚不完全清楚。本研究的主要目的是评估冰岛7岁儿童以及9岁儿童的维生素D状况，以及维生素D状况与骨矿物质含量和2年内骨量增加之间的关联。我们邀请了321名儿童参与本研究，267名（83%）儿童参与；211名（79%）儿童接受了双能X线吸收测定扫描，两年后其中164名再次接受扫描；159名（60%）儿童检测了维生素D样本，两年后其中119名（75%）再次进行检测。7岁时，65%的儿童维生素D浓度低于50 nmol/l，9岁时这一比例为60%。7岁时，43%的儿童维生素D量不足（37.5 - 50 nmol/l），22%的儿童维生素D缺乏（<37.5 nmol/l）。在线性回归分析中，未发现维生素D与骨矿物质含量之间存在关联。此外，与两个时间点维生素D浓度均超过50 nmol/l的儿童相比，两个年龄段维生素D不足或缺乏的儿童在2年内的骨量增加没有显著差异。超过60%的冰岛儿童在两年期间血清维生素D浓度反复不足。然而，该范围内的维生素D在7岁和9岁时对骨矿物质含量或骨量增加没有显著影响。
