Bock Jonathan M, Koszewski Ian J, Blumin Joel H, Toohill Robert J, Merati Albert L, Prieto Thomas E, Jaradeh Safwan S
Department of Otolaryngology & Communication Sciences, Medical College of Wisconsin, Milwaukee, Wisconsin.
Department of Otolaryngology & Communication Sciences, Medical College of Wisconsin, Milwaukee, Wisconsin.
J Voice. 2014 Sep;28(5):624-30. doi: 10.1016/j.jvoice.2014.02.009. Epub 2014 May 28.
Neurogenic chronic cough is currently a diagnosis of exclusion. We hypothesized that surface-evoked laryngeal sensory action potential (SELSAP) testing could be used to help establish a diagnosis of laryngeal sensory neuropathy as a cause of chronic cough, based on altered SELSAP waveform morphology.
Retrospective cohort study.
Laryngeal electromyographic (EMG) data including SELSAP waveform testing from patients with chronic cough were directly compared with a control population without significant laryngeal symptoms, and statistical analysis of unilateral and bilateral neuropathy injury subgroups was performed.
Thirty patients with a chief complaint of chronic cough underwent laryngeal EMG testing since January 2000 with needle EMG and surface nerve conduction studies. SELSAP waveform analysis of unilateral and bilateral laryngeal neuropathy demonstrated significantly lowered median SELSAP peak amplitude compared with controls (P < 0.01).
Patients with suspected neurogenic chronic cough demonstrate statistically significant alterations in SELSAP waveform that can support a diagnosis of laryngeal sensory neuropathy.
神经源性慢性咳嗽目前是一种排除性诊断。我们假设，基于表面诱发喉感觉动作电位（SELSAP）波形形态的改变，SELSAP检测可用于帮助诊断喉感觉神经病变作为慢性咳嗽的病因。
回顾性队列研究。
将慢性咳嗽患者的喉肌电图（EMG）数据（包括SELSAP波形检测）与无明显喉部症状的对照人群直接进行比较，并对单侧和双侧神经病变损伤亚组进行统计分析。
自2000年1月以来，30例以慢性咳嗽为主诉的患者接受了喉肌电图检测，包括针极肌电图和表面神经传导研究。单侧和双侧喉神经病变的SELSAP波形分析显示，与对照组相比，SELSAP峰值幅度中位数显著降低（P < 0.01）。
疑似神经源性慢性咳嗽的患者SELSAP波形有统计学意义的改变，可支持喉感觉神经病变的诊断。
