Hull J H, Menon A
Department of Respiratory Medicine, Royal Brompton Hospital, London SW3 6HP, UK.
Department of Respiratory Medicine, Royal Brompton Hospital, London SW3 6HP, UK.
Pulm Pharmacol Ther. 2015 Dec;35:111-6. doi: 10.1016/j.pupt.2015.08.008. Epub 2015 Aug 29.
Patients with chronic cough often report symptoms arising in the throat, in response to non-specific stimuli. Accordingly, the concept of a 'hypersensitivity' of the larynx in chronic cough has evolved over the past ten years. Patients with cough and laryngeal hypersensitivity frequently report features that overlap other laryngeal dysfunction syndromes, including a tendency for the vocal cords to inappropriately adduct. The mechanisms underlying laryngeal hypersensitivity in chronic cough are currently unclear, however recent studies provide new clinical and physiological techniques to aid detection and monitoring of laryngeal hypersensitivity. This review provides an overview of the current state of knowledge in this field.
慢性咳嗽患者常报告在咽喉部出现对非特异性刺激产生反应的症状。因此，在过去十年中，慢性咳嗽患者喉部“超敏反应”的概念逐渐形成。咳嗽伴喉部超敏反应的患者经常报告一些与其他喉部功能障碍综合征重叠的特征，包括声带不适当内收的倾向。目前尚不清楚慢性咳嗽中喉部超敏反应的潜在机制，然而最近的研究提供了新的临床和生理技术，以帮助检测和监测喉部超敏反应。本综述概述了该领域的当前知识状态。
