Fukutani Naoto, Yamada Minoru, Nishiguchi Shu, Yukutake Taiki, Kayama Hiroki, Tanigawa Takanori, Adachi Daiki, Hotta Takayuki, Morino Saori, Tashiro Yuto, Aoyama Tomoki, Tsuboyama Tadao
Department of Physical Therapy, Human Health Sciences, Kyoto University Graduate School of Medicine, 53 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto, 606-8507, Japan,
Aging Clin Exp Res. 2015 Feb;27(1):69-74. doi: 10.1007/s40520-014-0248-5. Epub 2014 Jun 1.
The aim of this study was to investigate the physiological characteristics of community-dwelling elderly subjects, aged ≥65 years, with airflow limitation in the Japanese community.
Subjects were recruited through local press advertisement, and 180 individuals were enrolled. Data on age, body mass index (BMI), gender, smoking history, and past medical history were obtained, as were pulmonary function parameters, skeletal muscle mass index, and physical activity.
The final study population comprised 161 participants from whom we obtained valid spirometry results. The mean age of this population was 73.4 ± 4.4 years, and 78 participants (48.4 %) were men. The prevalence of airflow limitation was 29.2 % (n = 47). Subjects with airflow limitation were significantly older (P = 0.01) and had poorer pulmonary function (P < 0.01), lower BMI (P < 0.01), and lower skeletal muscle mass index (P = 0.03) than healthy elderly subjects. Furthermore, skeletal muscle mass index was significantly correlated with the percentage of predicted forced vital capacity (r = 0.45, P < 0.05) and forced expiratory volume in 1 s (r = 0.50, P < 0.05) only in men with airflow limitation.
We found that the skeletal muscle mass index was significantly reduced in community-dwelling elderly with airflow limitation, and the skeletal muscle mass index was correlated with pulmonary function only in men with airflow limitation.
本研究旨在调查日本社区中年龄≥65岁且存在气流受限的居家老年人的生理特征。
通过当地报纸广告招募受试者，共纳入180人。收集了年龄、体重指数（BMI）、性别、吸烟史和既往病史等数据，以及肺功能参数、骨骼肌质量指数和身体活动情况。
最终研究人群包括161名参与者，我们获得了他们有效的肺量计检测结果。该人群的平均年龄为73.4±4.4岁，78名参与者（48.4%）为男性。气流受限的患病率为29.2%（n = 47）。与健康老年受试者相比，气流受限的受试者年龄显著更大（P = 0.01），肺功能更差（P < 0.01），BMI更低（P < 0.01），骨骼肌质量指数更低（P = 0.03）。此外，仅在气流受限的男性中，骨骼肌质量指数与预计用力肺活量百分比（r = 0.45，P < 0.05）和1秒用力呼气量（r = 0.50，P < 0.05）显著相关。
我们发现，气流受限的居家老年人骨骼肌质量指数显著降低，且仅在气流受限的男性中，骨骼肌质量指数与肺功能相关。
