Durakovic Z, Ivanovic D, Durakovic A
University Hospital, Department of Medicine, Zagreb, Yugoslavia.
Cardiovasc Drugs Ther. 1989 Jan;2(6):757-60. doi: 10.1007/BF00133205.
Digoxin concentrations in serum samples were measured before and after hemodialysis of 31 uremic patients (pts) who either never took digoxin or who had not taken digoxin for at least 1 year. False positive digoxin was found in 22 of 31 patients (71%) before hemodialysis and in 14 of 31 patients (45%) after hemodialysis. The concentrations ranged from 0.1 to 0.5 nmol/L, mean value was 0.20 +/- 0.16 before hemodialysis and after hemodialysis ranged 0.1 to 0.4 nmol/L mean value was 0.11 +/- 0.14 nmol/L. The difference before and after hemodialysis is statistically significant. Some of the patients had a constant value before and after hemodialysis. None had a higher value after hemodialysis than they did before. Eight patients, who had positive serum digoxin before hemodialysis with concentrations up to 0.5 nmol/L, became negative after hemodialysis. Our results indicate that a digoxinlike substance in uremic serum could be at least partly dialyzable.
对31例从未服用过地高辛或至少1年未服用地高辛的尿毒症患者进行血液透析前后血清样本中的地高辛浓度测定。血液透析前31例患者中有22例（71%）出现地高辛假阳性，血液透析后31例患者中有14例（45%）出现地高辛假阳性。浓度范围为0.1至0.5 nmol/L，血液透析前平均值为0.20±0.16，血液透析后范围为0.1至0.4 nmol/L，平均值为0.11±0.14 nmol/L。血液透析前后的差异具有统计学意义。部分患者血液透析前后值恒定。没有患者血液透析后的值高于透析前。8例血液透析前血清地高辛呈阳性、浓度高达0.5 nmol/L的患者，血液透析后转为阴性。我们的结果表明，尿毒症血清中的一种地高辛样物质至少部分可被透析清除。
