Gorantla Vikram C, Kirkwood John M
Division of Hematology/Oncology, Department of Medicine, School of Medicine, University of Pittsburgh, 5150 Centre Avenue, Pittsburgh, PA 15232, USA.
Division of Hematology/Oncology, Department of Medicine, School of Medicine, University of Pittsburgh, 5150 Centre Avenue, Pittsburgh, PA 15232, USA; Melanoma and Skin Cancer Program, University of Pittsburgh Cancer Institute, 5115 Centre Avenue, Suite 1.32, Pittsburgh, PA 15232, USA.
Hematol Oncol Clin North Am. 2014 Jun;28(3):415-35. doi: 10.1016/j.hoc.2014.02.010.
The last 30 years has seen a revolution in melanoma. Fundamental elements of the surgical, adjuvant medical, and systemic therapy for the disease have been significantly altered toward improved management and better outcomes. The intent of this article is to reflect on past efforts and research in melanoma and the current landscape of treatment of melanoma. The authors also hope to capture the excitement currently rippling through the field and the hope for a cure. The intent of treatment of advanced melanoma, which was once considered incurable, has changed from palliative to potentially curative.
过去30年见证了黑色素瘤领域的一场革命。该疾病的手术、辅助医疗及全身治疗的基本要素已发生显著改变，以实现更好的管理和更佳的治疗效果。本文旨在回顾黑色素瘤过去的研究成果以及当前的治疗现状。作者们还希望传达目前该领域所洋溢的兴奋之情以及治愈的希望。晚期黑色素瘤的治疗目的，曾被认为无法治愈，如今已从姑息治疗转变为可能治愈。
