心脏中河马信号通路的应用：河马/Yes相关蛋白信号通路及其在心脏再生与修复中的应用
Harnessing Hippo in the heart: Hippo/Yap signaling and applications to heart regeneration and rejuvenation.
作者信息
Lin Zhiqiang, Pu William T
机构信息
Department of Cardiology, Children's Hospital Boston, USA.
Department of Cardiology, Children's Hospital Boston, USA; Harvard Stem Cell Institute, Harvard University, USA.
出版信息
Stem Cell Res. 2014 Nov;13(3 Pt B):571-81. doi: 10.1016/j.scr.2014.04.010. Epub 2014 May 6.
Abstract
The adult mammalian heart exhibits limited regenerative capacity after myocardial injury, a shortcoming that is responsible for the current lack of definitive treatments for heart failure. A search for approaches that might enhance adult heart regeneration has led to interest in the Hippo/Yap signaling pathway, a recently discovered signaling pathway that regulates cell proliferation and organ growth. Here we provide a brief overview of the Hippo/Yap pathway and its known roles in the developing and adult heart. We discuss the implications of Hippo/Yap signaling for regulation of cardiomyocyte death and regeneration.
摘要
成年哺乳动物心脏在心肌损伤后再生能力有限，这一缺陷导致目前缺乏针对心力衰竭的确切治疗方法。对可能增强成年心脏再生的方法的探索引发了对Hippo/Yap信号通路的兴趣，这是一条最近发现的调节细胞增殖和器官生长的信号通路。在这里，我们简要概述Hippo/Yap通路及其在发育中和成年心脏中的已知作用。我们讨论了Hippo/Yap信号对心肌细胞死亡和再生调节的影响。
相似文献
1
Harnessing Hippo in the heart: Hippo/Yap signaling and applications to heart regeneration and rejuvenation.
Stem Cell Res. 2014 Nov;13(3 Pt B):571-81. doi: 10.1016/j.scr.2014.04.010. Epub 2014 May 6.
2
The Hippo pathway in the heart: pivotal roles in development, disease, and regeneration.
Nat Rev Cardiol. 2018 Nov;15(11):672-684. doi: 10.1038/s41569-018-0063-3.
3
The hippo pathway in heart development, regeneration, and diseases.
Circ Res. 2015 Apr 10;116(8):1431-47. doi: 10.1161/CIRCRESAHA.116.303311.
4
Hippo pathway effector Yap promotes cardiac regeneration.
Proc Natl Acad Sci U S A. 2013 Aug 20;110(34):13839-44. doi: 10.1073/pnas.1313192110. Epub 2013 Aug 5.
5
Regulation of Myocardial Cell Growth and Death by the Hippo Pathway.
Circ J. 2016 Jun 24;80(7):1511-9. doi: 10.1253/circj.CJ-16-0476. Epub 2016 Jun 10.
6
Hippo Deficiency Leads to Cardiac Dysfunction Accompanied by Cardiomyocyte Dedifferentiation During Pressure Overload.
Circ Res. 2019 Jan 18;124(2):292-305. doi: 10.1161/CIRCRESAHA.118.314048.
7
Dystrophin-glycoprotein complex sequesters Yap to inhibit cardiomyocyte proliferation.
Nature. 2017 Jul 13;547(7662):227-231. doi: 10.1038/nature22979. Epub 2017 Jun 5.
8
Hippo pathway inhibits Wnt signaling to restrain cardiomyocyte proliferation and heart size.
Science. 2011 Apr 22;332(6028):458-61. doi: 10.1126/science.1199010.
9
Upstream regulation of the Hippo-Yap pathway in cardiomyocyte regeneration.
Semin Cell Dev Biol. 2020 Apr;100:11-19. doi: 10.1016/j.semcdb.2019.09.004. Epub 2019 Oct 9.
10
Neddylation mediates ventricular chamber maturation through repression of Hippo signaling.
Proc Natl Acad Sci U S A. 2018 Apr 24;115(17):E4101-E4110. doi: 10.1073/pnas.1719309115. Epub 2018 Apr 9.
引用本文的文献
1
From gene to mechanics: a comprehensive insight into the mechanobiology of LMNA mutations in cardiomyopathy.
Cell Commun Signal. 2024 Mar 27;22(1):197. doi: 10.1186/s12964-024-01546-5.
2
Regulatory Mechanisms That Guide the Fetal to Postnatal Transition of Cardiomyocytes.
Cells. 2023 Sep 21;12(18):2324. doi: 10.3390/cells12182324.
3
Comparative Analysis of Heart Regeneration: Searching for the Key to Heal the Heart-Part II: Molecular Mechanisms of Cardiac Regeneration.
J Cardiovasc Dev Dis. 2023 Aug 22;10(9):357. doi: 10.3390/jcdd10090357.
4
Neonatal Cardiovascular-Progenitor-Cell-Derived Extracellular Vesicles Activate YAP1 in Adult Cardiac Progenitor Cells.
Int J Mol Sci. 2023 Apr 30;24(9):8088. doi: 10.3390/ijms24098088.
5
Neuregulin-1, a potential therapeutic target for cardiac repair.
Front Pharmacol. 2022 Aug 31;13:945206. doi: 10.3389/fphar.2022.945206. eCollection 2022.
6
Potential Role of Exercise in Regulating YAP and TAZ During Cardiomyocytes Aging.
Curr Cardiol Rev. 2022;18(5):24-33. doi: 10.2174/1573403X18666220404152924.
7
Hydrostatic Pressure Controls Angiogenesis Through Endothelial YAP1 During Lung Regeneration.
Front Bioeng Biotechnol. 2022 Feb 18;10:823642. doi: 10.3389/fbioe.2022.823642. eCollection 2022.
8
Targeting cardiomyocyte proliferation as a key approach of promoting heart repair after injury.
Mol Biomed. 2021 Nov 5;2(1):34. doi: 10.1186/s43556-021-00047-y.
9
Exercise Inhibits Doxorubicin-Induced Damage to Cardiac Vessels and Activation of Hippo/YAP-Mediated Apoptosis.
Cancers (Basel). 2021 Jun 1;13(11):2740. doi: 10.3390/cancers13112740.
10
Navigating the Crossroads of Cell Therapy and Natural Heart Regeneration.
Front Cell Dev Biol. 2021 May 11;9:674180. doi: 10.3389/fcell.2021.674180. eCollection 2021.
本文引用的文献
1
Hippo signaling impedes adult heart regeneration.
Development. 2013 Dec;140(23):4683-90. doi: 10.1242/dev.102798.
2
Actin-binding and cell proliferation activities of angiomotin family members are regulated by Hippo pathway-mediated phosphorylation.
J Biol Chem. 2013 Dec 27;288(52):37296-307. doi: 10.1074/jbc.M113.527598. Epub 2013 Nov 13.
3
Mst1 inhibits autophagy by promoting the interaction between Beclin1 and Bcl-2.
Nat Med. 2013 Nov;19(11):1478-88. doi: 10.1038/nm.3322. Epub 2013 Oct 20.
4
Phosphorylation of angiomotin by Lats1/2 kinases inhibits F-actin binding, cell migration, and angiogenesis.
J Biol Chem. 2013 Nov 22;288(47):34041-34051. doi: 10.1074/jbc.M113.518019. Epub 2013 Oct 8.
5
Serum deprivation inhibits the transcriptional co-activator YAP and cell growth via phosphorylation of the 130-kDa isoform of Angiomotin by the LATS1/2 protein kinases.
Proc Natl Acad Sci U S A. 2013 Oct 22;110(43):17368-73. doi: 10.1073/pnas.1308236110. Epub 2013 Oct 7.
6
Spatial organization of Hippo signaling at the plasma membrane mediated by the tumor suppressor Merlin/NF2.
Cell. 2013 Sep 12;154(6):1342-55. doi: 10.1016/j.cell.2013.08.025. Epub 2013 Sep 5.
7
Opposite feedbacks in the Hippo pathway for growth control and neural fate.
Science. 2013 Oct 11;342(6155):1238016. doi: 10.1126/science.1238016. Epub 2013 Aug 29.
8
Hippo pathway effector Yap promotes cardiac regeneration.
Proc Natl Acad Sci U S A. 2013 Aug 20;110(34):13839-44. doi: 10.1073/pnas.1313192110. Epub 2013 Aug 5.
9
TRIB2 acts downstream of Wnt/TCF in liver cancer cells to regulate YAP and C/EBPα function.
Mol Cell. 2013 Jul 25;51(2):211-25. doi: 10.1016/j.molcel.2013.05.013. Epub 2013 Jun 13.
10
The Hippo pathway: regulators and regulations.
Genes Dev. 2013 Feb 15;27(4):355-71. doi: 10.1101/gad.210773.112.
Zotero 插件