Postgraduate Program of Biomedical Science, PMDSU Program Batch V, Universitas Padjajaran, Bandung, Indonesia.
Department of Clinical Skills, Faculty of Medicine, Maranatha Christian University, Bandung, Indonesia.
Curr Cardiol Rev. 2022;18(5):24-33. doi: 10.2174/1573403X18666220404152924.
Adaptation of cardiac muscle to regular exercise results in morphological and structural changes known as physiological cardiac hypertrophy, to which the Hippo signaling pathway might have contributed. Two major terminal effectors in the Hippo signaling pathway are Yes-associated protein (YAP) and its homolog transcriptional coactivator with PDZ-binding motif (TAZ). The latest studies have reported the role of YAP and TAZ in different life stages, such as in fetal, neonatal, and adult hearts. Their regulation might involve several mechanisms and effectors. One of the possible coregulators is exercise. Exercise plays a role in cardiomyocyte hypertrophic changes during different stages of life, including in aged hearts. YAP/TAZ signaling pathway has a role in physiological cardiac hypertrophy induced by exercise and is associated with cardiac remodelling. Thus, it can be believed that exercise has roles in activating the signaling pathway of YAP and TAZ in aged cardiomyocytes. However, the studies regarding the roles of YAP and TAZ during cardiomyocyte aging are limited. The primary purpose of this review is to explore the response of cardiovascular aging to exercise via signaling pathway of YAP and TAZ.
心脏肌肉对规律运动的适应会导致形态和结构的变化，称为生理性心肌肥厚，Hippo 信号通路可能对此有贡献。Hippo 信号通路的两个主要终效物是 Yes 相关蛋白 (YAP) 和其同源转录共激活因子 PDZ 结合基序 (TAZ)。最新的研究报告了 YAP 和 TAZ 在不同生命阶段的作用，如胎儿、新生儿和成人心脏。它们的调节可能涉及多种机制和效应物。其中一个可能的共调节因子是运动。运动在生命不同阶段的心肌肥厚变化中发挥作用，包括老年心脏。YAP/TAZ 信号通路在运动诱导的生理性心肌肥厚中起作用，并与心脏重构有关。因此，可以认为运动在激活老年心肌细胞中 YAP 和 TAZ 的信号通路方面发挥作用。然而，关于 YAP 和 TAZ 在心肌细胞衰老过程中的作用的研究有限。本综述的主要目的是通过 YAP 和 TAZ 的信号通路探讨心血管衰老对运动的反应。
