miRNAs 在卵巢功能中的调控作用。

Regulatory role of microRNAs in ovarian function.

机构信息

IVF Unit, Department of Obstetrics and Gynecology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel; The Magda and Richard Hoffman Center for Human Placenta Research, Department of Obstetrics and Gynecology, Hadassah-Hebrew University Medical Center, Mount Scopus, Jerusalem, Israel.

The Magda and Richard Hoffman Center for Human Placenta Research, Department of Obstetrics and Gynecology, Hadassah-Hebrew University Medical Center, Mount Scopus, Jerusalem, Israel.

出版信息

Fertil Steril. 2014 Jun;101(6):1524-30. doi: 10.1016/j.fertnstert.2014.04.024.

DOI:10.1016/j.fertnstert.2014.04.024

PMID:24882616

Abstract

MicroRNAs have recently begun to be explored in ovarian cells, uncovering their influence on fundamental ovarian features like steroidogenesis, ovulation, and curpos luteum development and function. We provide a review of the current knowledge on microRNAs, specifically relating to human ovarian cell function and microRNAs' role in the ovarian physiologic process and ovulation dysfunction. Because of microRNAs' known stability in body fluids, we enlighten also their potential use in the clinical setting as novel biomarkers for ovarian function. Future research of the role of microRNAs in physiologic and dysfunctional ovulation may offer new diagnostic and treatment strategies for infertility and other ovarian disorders.

摘要

MicroRNAs 最近开始在卵巢细胞中被探索，揭示了它们对类固醇生成、排卵、黄体形成和功能等基本卵巢特征的影响。我们综述了 microRNAs 的现有知识，特别是与人类卵巢细胞功能以及 microRNAs 在卵巢生理过程和排卵功能障碍中的作用有关。由于 microRNAs 在体液中具有已知的稳定性，我们还阐明了它们在临床环境中的潜在用途，作为卵巢功能的新型生物标志物。microRNAs 在生理和功能障碍性排卵中的作用的未来研究可能为不孕和其他卵巢疾病提供新的诊断和治疗策略。