Department of Midwifery, Dezful Branch Islamic Azad University, Dezful, Iran.
Department of Midwifery, Dezful Branch Islamic Azad University, Dezful, Iran.
Biomed Pharmacother. 2018 Oct;106:1633-1640. doi: 10.1016/j.biopha.2018.07.073. Epub 2018 Jul 29.
Through the reproductive system, it has been realized that the microRNAs (miRNAs) have emerged as one of the principal post-transcriptional gene regulators of the diverse developmental processes. The ovary, as a dynamic organ, co-ordinates follicle recruitment, selection, and ovulation, in which miRNAs play the central role almost in its all functions. Deregulation of these developmental procedures in ovary could lead to the ovarian dysfunction, infertility, decrease in the assisted reproductive treatment (ART) outcome, and death in some patients with ovarian cancer. In recent years, detection of ovarian extracellular miRNAs in body fluids such as follicular fluid and serum/plasma has opened a new era in the biomarker discovery field. Here through the present review, different aspects of the potential and proposed involvement of the extracellular miRNAs in both physiologic and pathologic contexts of the ovary have been discussed. Moreover, the researchers have addressed the relevant findings, challenges, and issues which associated with the extracellular miRNAs in the ovarian microenvironments to provide the better insight into understanding the molecular mechanisms which were involved in the pathophysiologic conditions. Finally, a comprehensive survey of the gaps has been discussed to hopefully shed new light and perspective on the development of the novel diagnostic and therapeutic platforms in the clinic.
通过生殖系统，人们已经认识到微小 RNA（miRNAs）是各种发育过程中主要的转录后基因调控因子之一。卵巢作为一个动态器官，协调着卵泡的募集、选择和排卵，miRNAs 在其几乎所有功能中都起着核心作用。卵巢中这些发育过程的失调可能导致卵巢功能障碍、不孕、辅助生殖治疗（ART）结局下降，以及一些卵巢癌患者死亡。近年来，在卵泡液和血清/血浆等体液中检测到卵巢细胞外 miRNAs 开辟了生物标志物发现领域的新纪元。在这里，通过本综述，讨论了细胞外 miRNAs 在卵巢的生理和病理环境中的潜在作用和提出的参与。此外，研究人员还讨论了与卵巢微环境中外泌体 miRNAs 相关的相关发现、挑战和问题，以更好地了解参与病理生理条件的分子机制。最后，讨论了全面的差距，希望为临床新型诊断和治疗平台的发展提供新的思路和视角。
