用于检测口腔鳞状细胞癌的唾液生物标志物——现状与最新进展
Salivary biomarkers for detection of oral squamous cell carcinoma - current state and recent advances.
作者信息
Yakob Maha, Fuentes Laurel, Wang Marilene B, Abemayor Elliot, Wong David T W
机构信息
Center for Oral/Head & Neck Oncology Research, University of California, Los Angeles, 73-017 CHS, 10833 Le Conte Avenue, Los Angeles, CA 90095, U.S.A.
出版信息
Curr Oral Health Rep. 2014 Jun 1;1(2):133-141. doi: 10.1007/s40496-014-0014-y.
Abstract
Oral squamous cell carcinoma (OSCC) is the most common malignant neoplasm of the oral cavity. Detection of OSCC is currently based on thorough clinical oral examination combined with biopsy for histological analysis. Most cases of OSCC are not detected until the cancer has developed into advanced stages; thus, a reliable early stage diagnostic marker is needed. This literature review presents an overview of the status of current advances in salivary diagnostics for OSCC. Though many protein and mRNA salivary biomarkers have been identified that can detect OSCC with high sensitivity and specificity, the most discernable findings occur with the use of multiple markers. Studies that incorporate proteomic, transcriptomic, and potentially additional "omics", including methylomics, need to be initiated to bring technology to clinical applications and allow the best use of saliva in diagnosing OSCC.
摘要
口腔鳞状细胞癌（OSCC）是口腔最常见的恶性肿瘤。目前，OSCC的检测基于全面的口腔临床检查并结合活检进行组织学分析。大多数OSCC病例直到癌症发展到晚期才被发现；因此，需要一种可靠的早期诊断标志物。这篇文献综述概述了目前OSCC唾液诊断的进展情况。尽管已经鉴定出许多蛋白质和mRNA唾液生物标志物，它们能够以高灵敏度和特异性检测OSCC，但使用多种标志物时的发现最为明显。需要开展整合蛋白质组学、转录组学以及可能包括甲基组学等其他“组学”的研究，以便将技术应用于临床，并在诊断OSCC时充分利用唾液。
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