Mishra Akanksha, Saurabh Siddharth
Department of Pediatric and Preventive Dentistry, Bhabha College of Dental Sciences, Bhabha University, Bhopal, Madhya Pradesh, India.
Department of Oral Medicine and Maxillofacial Radiology, Bhabha College of Dental Sciences, Bhabha University, Bhopal, Madhya Pradesh, India.
Int J Clin Pediatr Dent. 2024 Sep;17(9):1044-1048. doi: 10.5005/jp-journals-10005-2937.
According to the World Health Organization, probiotics are live microorganisms that, when administered in adequate amounts, confer a health benefit to the host. The use of oral probiotics in children to improve oral health may lead to nonpathogenic bacteria replacing cariogenic bacteria. The Evora Plus oral probiotics tablet is the first such oral probiotics tablet containing a proprietary blend of three select species of naturally occurring oral bacteria, each with a specific function for maintaining a healthy oral environment. These strains include KJ3sm, KJ2sm, and JH145.
To compare the levels of salivary total bacterial count, salivary pH levels, and salivary count before and after consumption of the Evora Plus oral probiotic tablet.
Around 40 caries-free schoolchildren from Daksh International School, Gadarwara, Madhya Pradesh, India, aged 12-14 years, were selected and divided equally into two groups-group A, in which total salivary bacterial count and pH were evaluated, and group B, in which salivary count and pH were evaluated. These groups were further subdivided into group A1 and group B1, which served as the control groups not receiving the Evora Plus oral probiotic tablet, and group A2 and group B2, which were the test groups consuming the Evora Plus oral probiotic tablet for 30 days. Assessment of salivary samples for total bacterial count was done at baseline and after 30 days for groups A1 and B1. Salivary pH estimation was done at baseline and after 30 days for the entire group, and salivary count was done at baseline and after 30 days for groups A2 and B2. Salivary pH level was checked using a digital pH meter; nutrient agar was used for salivary total bacterial count, while Mitis salivarius bacitracin agar was used for salivary count. The number of colonies was counted and subjected to statistical analysis using unpaired and paired Student's -test.
The study showed a significant reduction in salivary total bacterial count and salivary counts, as well as a significant increase in salivary pH after 30 days in the Evora Plus oral probiotic group compared with the group not receiving the Evora Plus oral probiotic tablet.
Cariogenic microorganisms could be reduced by an oral probiotic formulation. Thus, the use of the Evora Plus oral probiotic tablet could be recommended for the prevention of enamel demineralization.
Mishra A, Saurabh S. EvoraPlus Oral Probiotic Tablet: New paradigm for Caries Prevention in Children. Int J Clin Pediatr Dent 2024;17(9):1044-1048.
根据世界卫生组织的定义，益生菌是一类活的微生物，当给予足够数量时，能给宿主带来健康益处。在儿童中使用口服益生菌来改善口腔健康，可能会使非致病性细菌取代致龋菌。Evora Plus口服益生菌片是首款此类口服益生菌片，它含有三种精选的天然口腔细菌的专利混合物，每种细菌在维持健康口腔环境方面都有特定功能。这些菌株包括KJ3sm、KJ2sm和JH145。
比较服用Evora Plus口服益生菌片前后唾液中总细菌计数、唾液pH值水平以及唾液[具体细菌名称未明确给出]计数。
从印度中央邦加德瓦拉的达克什国际学校挑选了约40名12 - 14岁无龋齿的学童，将他们平均分为两组——A组，评估唾液总细菌计数和pH值；B组，评估唾液[具体细菌名称未明确给出]计数和pH值。这些组进一步细分为A1组和B1组，作为未服用Evora Plus口服益生菌片的对照组；以及A2组和B2组，作为服用Evora Plus口服益生菌片30天的试验组。A1组和B1组在基线和30天后对唾液样本进行总细菌计数评估。对整个组在基线和30天后进行唾液pH值估计，对A2组和B2组在基线和30天后进行唾液[具体细菌名称未明确给出]计数。使用数字pH计检查唾液pH值水平；营养琼脂用于唾液总细菌计数，而唾液链球菌杆菌肽琼脂用于唾液[具体细菌名称未明确给出]计数。计算菌落数，并使用不成对和配对的学生t检验进行统计分析。
研究表明，与未服用Evora Plus口服益生菌片的组相比，Evora Plus口服益生菌组在30天后唾液总细菌计数和唾液[具体细菌名称未明确给出]计数显著降低，唾液pH值显著升高。
口服益生菌制剂可减少致龋微生物。因此，可推荐使用Evora Plus口服益生菌片来预防牙釉质脱矿。
Mishra A, Saurabh S. EvoraPlus Oral Probiotic Tablet: New paradigm for Caries Prevention in Children. Int J Clin Pediatr Dent 2024;17(9):1044 - 1048.
