Yoon Chong Hyeok, Kang Sang Kyu, Jin Chan Hee, Park Moon Sun, Rho Jeong Hoon
Department of Obstetrics and Gynecology, Eulji University Medical Center, Eulji University College of Medicine, Daejeon, Korea.
Department of Neurosurgery, Eulji University Medical Center, Eulji University College of Medicine, Daejeon, Korea.
Obstet Gynecol Sci. 2014 May;57(3):223-7. doi: 10.5468/ogs.2014.57.3.223. Epub 2014 May 15.
Neural tube defects are the major targets of prenatal diagnoses, along with Down syndrome. Prenatal diagnosis of spina bifida is possible at second trimester of gestation through α-fetoprotein and acetylcholinesterase biochemistry assays and ultrasound. In particular, the discovery of characteristic intracranial signs on ultrasound leads to a very high diagnosis rate. However, it is rare for spina bifida to present without intracranial signs while also showing normal values of maternal serum α-fetoprotein, amniotic fluid α-fetoprotein, and acetylcholinesterase. In our hospital, a fetus with spina bifida was delivered at 37+5 weeks' gestation by cesarean section, and was continually followed up over 2 years to date.
神经管缺陷与唐氏综合征一样，是产前诊断的主要对象。妊娠中期可通过甲胎蛋白和乙酰胆碱酯酶生化检测及超声对脊柱裂进行产前诊断。特别是，超声检查发现特征性颅内体征可使诊断率非常高。然而，脊柱裂在无颅内体征且母体血清甲胎蛋白、羊水甲胎蛋白和乙酰胆碱酯酶值均正常的情况下出现的情况很少见。在我院，一名患有脊柱裂的胎儿于妊娠37 + 5周时剖宫产分娩，至今已持续随访2年。
