通过α-亚氨基重氮中间体一步合成含氮中型环。
One-step synthesis of nitrogen-containing medium-sized rings via α-imino diazo intermediates.
机构信息
Department of Organic Chemistry, University of Geneva , 30 Quai Ernest Ansermet, CH-1211 Geneva 4, Switzerland.
出版信息
Org Lett. 2014 Jun 20;16(12):3232-5. doi: 10.1021/ol5012532. Epub 2014 Jun 2.
PMID:24885761
Abstract
Eight- and 9-membered dioxazocines and dioxazonines are readily synthesized starting from N-sulfonyl-1,2,3-triazoles in a single-step procedure. A perfect regioselectivity and generally good yields (up to 92%) are obtained under dirhodium catalysis using 1,3-dioxolane and 1,3-dioxane as solvents and reagents.
摘要
八元和九元的二噁氮杂环辛烷和二噁氮杂环庚烷可由 N-磺酰基-1,2,3-三唑一步法合成。在双铑催化下，使用 1,3-二氧戊环和 1,3-二氧杂环己烷作为溶剂和试剂，可获得完美的区域选择性和一般良好的收率（高达 92%）。
Zotero 插件