偕二氮杂茂与异硫氰酸酯和黄原酸酯的共催化转环反应。
Co-Catalyzed Transannulation of Pyridotriazoles with Isothiocyanates and Xanthate Esters.
机构信息
Department of Chemistry and Biochemistry, University of Texas at Dallas, 800 W. Campbell Road, Richardson, Texas 75080, United States.
出版信息
Org Lett. 2020 Nov 6;22(21):8500-8504. doi: 10.1021/acs.orglett.0c03099. Epub 2020 Oct 12.
Abstract
An efficient radical transannulation reaction of pyridotriazoles with isothiocyanates and xanthate esters was developed. This method features conversion of pyridotriazoles into two -fused heterocyclic aromatic systems-imino-thiazolopyridines and oxo-thiazolopyridine derivatives-via one-step Co(II)-catalyzed transannulation reaction proceeding via a radical mechanism. The synthetic usefulness of the developed method was illustrated in the synthesis of amino acid derivatives and further transformations of obtained reaction products.
摘要
发展了一种吡啶并三唑与异硫氰酸酯和黄原酸酯的高效自由基交叉偶联反应。该方法通过 Co(II)催化的自由基反应一步转化吡啶并三唑生成两个稠合杂环芳香体系——亚氨基噻唑并吡啶和氧代噻唑并吡啶衍生物，具有较高的应用价值。所开发的方法在氨基酸衍生物的合成以及获得的反应产物的进一步转化中得到了应用。
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