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镍催化的N-磺酰基-1,2,3-三唑的脱氮炔烃插入反应

Nickel-catalysed denitrogenative alkyne insertion reactions of N-sulfonyl-1,2,3-triazoles.

作者信息

Miura Tomoya, Yamauchi Motoshi, Murakami Masahiro

机构信息

Department of Synthetic Chemistry and Biological Chemistry, Kyoto University, Katsura, Kyoto 615-8510, Japan.

出版信息

Chem Commun (Camb). 2009 Mar 28(12):1470-1. doi: 10.1039/b819162j. Epub 2009 Jan 6.

DOI:10.1039/b819162j
PMID:19277359
Abstract

N-Sulfonyl-1,2,3-triazoles reacted with alkynes in the presence of a nickel(0)/phosphine catalyst to give substituted pyrroles, with the extrusion of molecular nitrogen; the triazole moiety isomerised to an alpha-imino diazo species, and the denitrogenative addition to nickel(0) was followed by the insertion of alkynes and reductive elimination.

摘要

N-磺酰基-1,2,3-三唑在镍(0)/膦催化剂存在下与炔烃反应生成取代吡咯，并释放出分子氮；三唑部分异构化为α-亚氨基重氮物种，镍(0)的脱氮加成反应之后是炔烃的插入和还原消除反应。

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