精子生理学中的细胞内 pH 值。
Intracellular pH in sperm physiology.
机构信息
Departamento de Genética del Desarrollo y Fisiología Molecular, Instituto de Biotecnología, Universidad Nacional Autónoma de México, Cuernavaca, Morelos, 62210, Mexico.
Departamento de Genética del Desarrollo y Fisiología Molecular, Instituto de Biotecnología, Universidad Nacional Autónoma de México, Cuernavaca, Morelos, 62210, Mexico.
出版信息
Biochem Biophys Res Commun. 2014 Aug 1;450(3):1149-58. doi: 10.1016/j.bbrc.2014.05.100. Epub 2014 Jun 2.
Intracellular pH (pHi) regulation is essential for cell function. Notably, several unique sperm ion transporters and enzymes whose elimination causes infertility are either pHi dependent or somehow related to pHi regulation. Amongst them are: CatSper, a Ca(2+) channel; Slo3, a K(+) channel; the sperm-specific Na(+)/H(+) exchanger and the soluble adenylyl cyclase. It is thus clear that pHi regulation is of the utmost importance for sperm physiology. This review briefly summarizes the key components involved in pHi regulation, their characteristics and participation in fundamental sperm functions such as motility, maturation and the acrosome reaction.
细胞内 pH 值（pHi）调节对于细胞功能至关重要。值得注意的是，几种独特的精子离子转运体和酶，其缺失会导致不育，它们要么依赖于 pHi 调节，要么与 pHi 调节有关。其中包括：CatSper，一种 Ca(2+)通道；Slo3，一种 K(+)通道；精子特异性 Na(+)/H(+)交换器和可溶性腺苷酸环化酶。因此，很明显，pHi 调节对于精子生理学至关重要。本综述简要总结了参与 pHi 调节的关键成分、它们的特征以及它们在精子运动、成熟和顶体反应等基本功能中的参与。
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