Centre for Epidemiology and Biostatistics, School of Population and Global Health, The University of Melbourne, Carlton, Vic., Australia.
Allergy. 2014 Nov;69(11):1440-53. doi: 10.1111/all.12454. Epub 2014 Jul 12.
Asthma and allergy may develop as a result of interactions between environmental factors and the genetic characteristics of an individual. This review aims to summarize the available evidence for, and potential effects of, an interaction between polymorphisms of the CD14 gene and exposure to microbes on the risk of asthma and allergic diseases. We searched PubMed, MEDLINE and Global Health databases, finding 12 articles which met inclusion criteria. Most studies reported a significant interaction between CD14 polymorphisms and microbial exposure. When stratified by age at microbial exposure (early life vs adult life), there was evidence of a protective effect of gene-environment interaction against atopy in children, but not adults. We also found different effects of interaction depending on the type of microbial exposures. There was no strong evidence for asthma and eczema. Future studies should consider a three-way interaction between CD14 gene polymorphisms, microbial exposures and the age of exposure.
哮喘和过敏可能是由于环境因素和个体遗传特征之间的相互作用而发展的。本综述旨在总结 CD14 基因多态性与微生物暴露之间相互作用的现有证据及其对哮喘和过敏性疾病风险的潜在影响。我们检索了 PubMed、MEDLINE 和全球卫生数据库，找到了符合纳入标准的 12 篇文章。大多数研究报告 CD14 多态性与微生物暴露之间存在显著的相互作用。按微生物暴露的年龄（生命早期与成年期）分层时，发现基因-环境相互作用对儿童特应性具有保护作用，但对成年人没有。我们还发现了相互作用的不同影响取决于微生物暴露的类型。对哮喘和湿疹没有强有力的证据。未来的研究应考虑 CD14 基因多态性、微生物暴露和暴露年龄之间的三向相互作用。
