Ferrara A, Grassi G, Piccioni P D, Colombo M L, Gialdroni Grassi G
G Ital Chemioter. 1989 Jan-Dec;36(1-3):45-52.
Bacitracin and neomycin have been used for a long time for local intestinal antisepsis or decontamination, due to their scarce or nonexistent intestinal absorption. The aim of the present study was to determine the activity of bacitracin and neomycin against recent clinical isolates of aerobic and anaerobic microorganisms and to verify their capacity to have a synergistic effect and to prevent the emergence of bacterial resistance when in combination. The results showed that the activity of either antibiotic against recent clinical isolates (even if resistant to cephalosporins and aminoglycosides) is similar to that originally displayed at the time introduction in therapy. Generally the combination of the two antibiotics showed a synergistic or additive effect and prevented the selection of resistant strains.
杆菌肽和新霉素长期以来一直用于局部肠道抗菌或净化，因为它们在肠道中的吸收很少或不存在。本研究的目的是确定杆菌肽和新霉素对近期临床分离的需氧和厌氧微生物的活性，并验证它们联合使用时产生协同作用和防止细菌耐药性出现的能力。结果表明，这两种抗生素中任何一种对近期临床分离株（即使对头孢菌素和氨基糖苷类耐药）的活性与最初用于治疗时所显示的活性相似。一般来说，这两种抗生素联合使用显示出协同或相加作用，并可防止耐药菌株的产生。
