抗性 H-2(b) 单倍型的小鼠针对 9 种不同的 Friend 病毒表位产生广泛的 CD4(+) T 细胞反应。
Mice of the resistant H-2(b) haplotype mount broad CD4(+) T cell responses against 9 distinct Friend virus epitopes.
机构信息
Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, NIAID, NIH, Hamilton, MT 59840, USA.
Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, NIAID, NIH, Hamilton, MT 59840, USA.
出版信息
Virology. 2014 May;456-457:139-44. doi: 10.1016/j.virol.2014.03.012. Epub 2014 Apr 5.
Abstract
To date, only a single Friend virus (FV) peptide recognized by CD4(+) T cells in FV-infected mice of the resistant H-2(b) haplotype has been described. To more thoroughly examine the repertoire of CD4(+) T cell responses in H-2(b) mice infected with this retrovirus, 18mer peptides spanning the FV gag, pol, and env coding regions with 11mer overlaps were synthesized. The peptides were then used to stimulate whole splenocytes and purified CD4(+) T cells from FV-infected mice in an IFNγ ELISPOT assay. Nine new CD4(+) T cell epitopes were identified, 3 encoded by gag, 1 by pol, and 5 by env. The high resistance of H-2(b) mice could be related to this very broad CD4(+) T cell response against multiple peptides during FV infection.
摘要
迄今为止，仅在具有抗性 H-2(b) 单倍型的 FV 感染小鼠中描述了一种被 CD4(+) T 细胞识别的 Friend 病毒 (FV) 肽。为了更彻底地研究感染这种逆转录病毒的 H-2(b) 小鼠中 CD4(+) T 细胞反应的组成，合成了跨越 FV gag、pol 和 env 编码区的 18 个氨基酸肽，重叠 11 个氨基酸。然后，这些肽被用于刺激 IFNγ ELISPOT 测定中来自 FV 感染小鼠的全脾细胞和纯化的 CD4(+) T 细胞。鉴定了 9 个新的 CD4(+) T 细胞表位，其中 3 个由 gag 编码，1 个由 pol 编码，5 个由 env 编码。H-2(b) 小鼠的高抗性可能与 FV 感染期间针对多种肽的这种非常广泛的 CD4(+) T 细胞反应有关。
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1
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PLoS Pathog. 2012;8(5):e1002709. doi: 10.1371/journal.ppat.1002709. Epub 2012 May 10.
2
Distinct roles of CD4+ T cell subpopulations in retroviral immunity: lessons from the Friend virus mouse model.CD4+ T 细胞亚群在逆转录病毒免疫中的不同作用：来自 Friend 病毒小鼠模型的启示。
Retrovirology. 2011 Sep 26;8:76. doi: 10.1186/1742-4690-8-76.
3
Peptide binding predictions for HLA DR, DP and DQ molecules.HLA-DR、DP 和 DQ 分子的肽结合预测。
BMC Bioinformatics. 2010 Nov 22;11:568. doi: 10.1186/1471-2105-11-568.
4
Constraints within major histocompatibility complex class I restricted peptides: presentation and consequences for T-cell recognition.主要组织相容性复合体 I 类限制肽内的限制因素：呈递和对 T 细胞识别的影响。
Proc Natl Acad Sci U S A. 2010 Mar 23;107(12):5534-9. doi: 10.1073/pnas.1000032107. Epub 2010 Mar 8.
5
Mechanisms of control of acute Friend virus infection by CD4+ T helper cells and their functional impairment by regulatory T cells.CD4+T 辅助细胞对急性 Friend 病毒感染的控制机制及其被调节性 T 细胞功能障碍的影响。
J Gen Virol. 2010 Feb;91(Pt 2):440-51. doi: 10.1099/vir.0.015834-0. Epub 2009 Oct 14.
6
Race between retroviral spread and CD4+ T-cell response determines the outcome of acute Friend virus infection.逆转录病毒传播与CD4+ T细胞反应之间的竞赛决定了急性Friend病毒感染的结果。
J Virol. 2009 Nov;83(21):11211-22. doi: 10.1128/JVI.01225-09. Epub 2009 Aug 19.
7
Lymphocytic choriomeningitis virus infection yields overlapping CD4+ and CD8+ T-cell responses.淋巴细胞性脉络丛脑膜炎病毒感染会产生重叠的CD4 +和CD8 + T细胞反应。
J Virol. 2008 Dec;82(23):11734-41. doi: 10.1128/JVI.00435-08. Epub 2008 Oct 1.
8
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9
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PLoS Comput Biol. 2008 Apr 4;4(4):e1000048. doi: 10.1371/journal.pcbi.1000048.
10
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