Institute for Virology, University Clinics Essen, University of Duisburg-Essen, Germany.
Retrovirology. 2011 Sep 26;8:76. doi: 10.1186/1742-4690-8-76.
It is well established that CD4(+) T cells play an important role in immunity to infections with retroviruses such as HIV. However, in recent years CD4(+) T cells have been subdivided into several distinct populations that are differentially regulated and perform widely varying functions. Thus, it is important to delineate the separate roles of these subsets, which range from direct antiviral activities to potent immunosuppression. In this review, we discuss contributions from the major CD4(+) T cell subpopulations to retroviral immunity. Fundamental concepts obtained from studies on numerous viral infections are presented along with a more detailed analysis of studies on murine Friend virus. The relevance of these studies to HIV immunology and immunotherapy is reviewed.
已证实，CD4(+) T 细胞在针对 HIV 等逆转录病毒的感染免疫中发挥着重要作用。然而，近年来 CD4(+) T 细胞已被进一步细分为几个不同的亚群，这些亚群在调控和功能上存在广泛差异。因此，明确这些亚群的不同作用非常重要，这些作用的范围从直接抗病毒活性到强烈的免疫抑制。在这篇综述中，我们讨论了主要的 CD4(+) T 细胞亚群在逆转录病毒免疫中的贡献。我们展示了从对多种病毒感染的研究中获得的基本概念，以及对鼠源性 Friend 病毒的更详细分析。我们还回顾了这些研究对 HIV 免疫学和免疫疗法的相关性。
