The Pirbright Institute, Surrey GU24 0NF, United Kingdom;
The Roslin Institute University of Edinburgh, Midlothian EH259RG, United Kingdom; and.
J Immunol. 2014 Jul 1;193(1):208-22. doi: 10.4049/jimmunol.1303398. Epub 2014 Jun 2.
In humans and mice, γδ T cells represent <5% of the total circulating lymphocytes. In contrast, the γδ T cell compartment in ruminants accounts for 15-60% of the total circulating mononuclear lymphocytes. Despite the existence of CD4(+)CD25(high) Foxp3(+) T cells in the bovine system, these are neither anergic nor suppressive. We present evidence showing that bovine γδ T cells are the major regulatory T cell subset in peripheral blood. These γδ T cells spontaneously secrete IL-10 and proliferate in response to IL-10, TGF-β, and contact with APCs. IL-10-expressing γδ T cells inhibit Ag-specific and nonspecific proliferation of CD4(+) and CD8(+) T cells in vitro. APC subsets expressing IL-10 and TFG-β regulate proliferation of γδ T cells producing IL-10. We propose that γδ T cells are a major regulatory T cell population in the bovine system.
在人类和小鼠中，γδ T 细胞占总循环淋巴细胞的<5%。相比之下，反刍动物的 γδ T 细胞在总循环单核细胞中的比例占 15-60%。尽管在牛系统中存在 CD4(+)CD25(high)Foxp3(+)T 细胞，但它们既没有无反应性也没有抑制性。我们提供的证据表明，牛 γδ T 细胞是外周血中主要的调节性 T 细胞亚群。这些 γδ T 细胞自发分泌 IL-10，并对 IL-10、TGF-β 和与 APC 的接触作出增殖反应。表达 IL-10 的 γδ T 细胞在体外抑制 Ag 特异性和非特异性的 CD4(+)和 CD8(+)T 细胞增殖。表达 IL-10 和 TGF-β 的 APC 亚群调节产生 IL-10 的 γδ T 细胞的增殖。我们提出，γδ T 细胞是牛系统中主要的调节性 T 细胞群体。
