皮肤科中的细胞疗法。
Cell therapy in dermatology.
作者信息
Petrof Gabriela, Abdul-Wahab Alya, McGrath John A
机构信息
St. John's Institute of Dermatology, King's College London (Guy's Campus), London SE1 1UL, United Kingdom.
出版信息
Cold Spring Harb Perspect Med. 2014 Jun 2;4(6):a015156. doi: 10.1101/cshperspect.a015156.
Abstract
Harnessing the regenerative capacity of keratinocytes and fibroblasts from human skin has created new opportunities to develop cell-based therapies for patients. Cultured cells and bioengineered skin products are being used to treat patients with inherited and acquired skin disorders associated with defective skin, and further clinical trials of new products are in progress. The capacity of extracutaneous sources of cells such as bone marrow is also being investigated for its plasticity in regenerating skin, and new strategies, such as the derivation of inducible pluripotent stem cells, also hold great promise for future cell therapies in dermatology. This article reviews some of the preclinical and clinical studies and future directions relating to cell therapy in dermatology, particularly for inherited skin diseases associated with fragile skin and poor wound healing.
摘要
利用人类皮肤中的角质形成细胞和成纤维细胞的再生能力，为开发针对患者的细胞疗法创造了新机会。培养的细胞和生物工程皮肤产品正被用于治疗患有与皮肤缺陷相关的遗传性和获得性皮肤病的患者，并且新产品的进一步临床试验正在进行中。诸如骨髓等皮肤外细胞来源在再生皮肤方面的可塑性也正在被研究，并且新的策略，如诱导多能干细胞的衍生，对未来皮肤病学的细胞疗法也具有很大的前景。本文综述了一些与皮肤病学细胞疗法相关的临床前和临床研究以及未来方向，特别是针对与皮肤脆弱和伤口愈合不良相关的遗传性皮肤病。
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