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潜在的间充质干细胞治疗皮肤病。

Potential mesenchymal stem cell therapy for skin diseases.

机构信息

Department of Dermatology, Kurume University School of Medicine, Kurume University Institute of Cutaneous Cell Biology, Kurume, Fukuoka, Japan.

出版信息

Exp Dermatol. 2013 Aug;22(8):515-6. doi: 10.1111/exd.12194.

DOI:10.1111/exd.12194
PMID:23879810
Abstract

Mesenchymal stem cells (MSCs) are non-haematopoietic cells that reside in most tissues including adult bone marrow. MSCs have recently been extensively studied and used for clinical therapies, including skin wound healing. However, there are still many questions to be answered. In the viewpoint entitled 'Mesenchymal stem cell therapy in skin: why and what for?', Dr. Khosrotehrani provided a comprehensive overview for MSC properties and current progresses on clinical applications for various skin conditions. This viewpoint is therefore very helpful for both dermatologists and basic skin researchers to understand stem cells researches.

摘要

间充质干细胞(MSCs)是存在于大多数组织中的非造血细胞,包括成人骨髓。MSCs 最近得到了广泛的研究,并被用于临床治疗,包括皮肤伤口愈合。然而,仍有许多问题需要解答。在题为“间充质干细胞治疗皮肤:为何以及为何?”的观点中,Khosrotehrani 博士全面概述了 MSC 的特性以及在各种皮肤疾病的临床应用中的最新进展。因此,这一对观点对于皮肤科医生和基础皮肤研究人员理解干细胞研究都非常有帮助。

相似文献

1
Potential mesenchymal stem cell therapy for skin diseases.潜在的间充质干细胞治疗皮肤病。
Exp Dermatol. 2013 Aug;22(8):515-6. doi: 10.1111/exd.12194.
2
Mesenchymal stem cell therapy in skin: why and what for?间质干细胞疗法在皮肤中的应用:为何与何为?
Exp Dermatol. 2013 May;22(5):307-10. doi: 10.1111/exd.12141.
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Skin mesenchymal stem cells: prospects for clinical dermatology.皮肤间充质干细胞:临床皮肤科的前景。
J Am Acad Dermatol. 2010 Nov;63(5):859-65. doi: 10.1016/j.jaad.2009.09.022. Epub 2010 May 14.
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The role of bone marrow mesenchymal stromal cell derivatives in skin wound healing in diabetic mice.骨髓间充质基质细胞衍生物在糖尿病小鼠皮肤伤口愈合中的作用。
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Use of mesenchymal stem cells for cutaneous repair and skin substitute elaboration.间充质干细胞在皮肤修复和皮肤替代物制备中的应用。
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Evaluation of bone marrow derived mesenchymal stem cells for full-thickness wound healing in comparison to tissue engineered chitosan scaffold in rabbit.兔骨髓间充质干细胞与组织工程壳聚糖支架用于全层伤口愈合的比较评估
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Mesenchymal stromal cells for cutaneous wound healing in a rabbit model: pre-clinical study applicable in the pediatric surgical setting.间充质基质细胞用于兔模型皮肤伤口愈合:适用于小儿外科手术环境的临床前研究
J Transl Med. 2015 Jul 8;13:219. doi: 10.1186/s12967-015-0580-3.
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Mesenchymal stromal cells: properties and role in management of cutaneous diseases.间充质基质细胞:特性及其在皮肤病管理中的作用
J Eur Acad Dermatol Venereol. 2017 Mar;31(3):414-423. doi: 10.1111/jdv.13934. Epub 2016 Sep 19.
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Bone marrow mesenchymal stem cells accelerate the hyperglycemic refractory wound healing by inhibiting an excessive inflammatory response.骨髓间充质干细胞通过抑制过度的炎症反应加速高血糖难治性伤口愈合。
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Strategies to retain properties of bone marrow-derived mesenchymal stem cells ex vivo.体外保留骨髓间充质干细胞特性的策略。
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引用本文的文献

1
Immunomodulatory oligonucleotide IMT504: Effects on mesenchymal stem cells as a first-in-class immunoprotective/immunoregenerative therapy.免疫调节寡核苷酸IMT504:作为一类首创的免疫保护/免疫再生疗法对间充质干细胞的影响。
World J Stem Cells. 2017 Mar 26;9(3):45-67. doi: 10.4252/wjsc.v9.i3.45.
2
Multidisciplinary approaches to stimulate wound healing.促进伤口愈合的多学科方法。
Ann N Y Acad Sci. 2016 Aug;1378(1):137-142. doi: 10.1111/nyas.13158. Epub 2016 Jul 19.