质子通道对免疫反应的调节
Regulation of immune responses by proton channels.
作者信息
Capasso Melania
机构信息
Centre for Cancer and Inflammation, Barts Cancer Institute, Queen Mary University of London, London, UK.
出版信息
Immunology. 2014 Oct;143(2):131-7. doi: 10.1111/imm.12326.
Abstract
The identification of the HVCN1 gene, encoding the only mammalian voltage-gated proton channel, prompted a number of studies on how proton channels affect cellular functions. As their expression is mainly restricted to immune cells, it is not surprising that proton channels regulate different aspects of immune responses. In this review, I will examine the current knowledge of voltage-gated proton channels in both innate and adaptive responses and assess the remaining outstanding questions.
摘要
编码唯一哺乳动物电压门控质子通道的HVCN1基因的鉴定，引发了一系列关于质子通道如何影响细胞功能的研究。由于它们的表达主要局限于免疫细胞，质子通道调节免疫反应的不同方面也就不足为奇了。在这篇综述中，我将审视关于电压门控质子通道在先天性和适应性免疫反应中的现有知识，并评估仍未解决的突出问题。
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