Fidanza M, Dentini M, Crescenzi V, Del Vecchio P
Department of Chemistry, University La Sapienza, Rome, Italy.
Int J Biol Macromol. 1989 Dec;11(6):372-6. doi: 10.1016/0141-8130(89)90010-x.
Viscosity, optical activity, and differential scanning calorimetry data clearly point out that partial and/or total removal of charged substituent groups, i.e. succinate and pyruvyl residues, from succinoglycan lead to water soluble derivatives exhibiting a higher stability order----disorder conformational changes with respect to the native polysaccharide. The new succinoglycan derivatives also exhibit very little, if any, hysteresis upon 'renaturation' (cooling) as opposed to the case of the parent polymer. The absence of ionized groups is thus beneficial, thermodynamically and kinetically, to the attainment in dilute aqueous solution of an ordered conformation by the uncharged succinoglycan backbone, as allowed by the regular enchainment of its constituent sugar residues.
粘度、旋光性和差示扫描量热法数据清楚地表明，从琥珀酰聚糖中部分和/或完全去除带电取代基，即琥珀酸酯和丙酮酰残基，会产生水溶性衍生物，相对于天然多糖，这些衍生物表现出更高的稳定性顺序——有序-无序构象变化。与母体聚合物的情况相反，新的琥珀酰聚糖衍生物在“复性”（冷却）时几乎没有滞后现象（如果有的话）。因此，不存在离子化基团在热力学和动力学上有利于不带电的琥珀酰聚糖主链在稀水溶液中获得有序构象，这是由其组成糖残基的规则连接所允许的。
