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对风险和检测结果的误判延误了一名肺栓塞患者的诊断。

Misinterpreting risk and test results delays diagnosis in a patient with pulmonary embolism.

作者信息

Babak Sam, Sriram Krishna B

机构信息

Department of Respiratory Medicine, Gold Coast University Hospital, Gold Coast, Queensland, Australia.

School of Medicine, Griffith University, Queensland, Australia.

出版信息

BMJ Case Rep. 2014 Jun 2;2014:bcr2014204172. doi: 10.1136/bcr-2014-204172.

DOI:10.1136/bcr-2014-204172
PMID:24891483
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4054501/
Abstract

We report the case of a middle-aged man where a diagnosis of pulmonary embolism (PE) was delayed due to initial underestimation of risk and over-reliance on D-dimer testing. The patient presented with pleuritic chest pain after a 5 h domestic flight. The treating clinicians presumed that this duration of immobilisation was insufficient to cause a PE, D-dimer was not measured and the patient was discharged home. One week later, the patient re-presented due to persistence of chest pain. On this occasion, D-dimer was measured and it was normal, which was interpreted as excluding a PE. Subsequently, a CT pulmonary angiogram was performed, which demonstrated a subsegmental PE. This case highlights the importance of accurate assessment of PE-risk factors and following clinical guidelines, since a delayed diagnosis of PE is associated with increased mortality.

摘要

我们报告了一例中年男性病例,其肺栓塞(PE)的诊断因最初对风险的低估和对D - 二聚体检测的过度依赖而延迟。患者在进行了5小时的国内航班飞行后出现胸膜炎性胸痛。主治医生推测这种制动时间不足以导致肺栓塞,未检测D - 二聚体,患者被送回家。一周后,患者因胸痛持续而复诊。此次检测了D - 二聚体,结果正常,这被解读为排除了肺栓塞。随后进行了CT肺动脉造影,显示为亚段肺栓塞。该病例凸显了准确评估肺栓塞风险因素并遵循临床指南的重要性,因为肺栓塞的延迟诊断与死亡率增加相关。

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引用本文的文献

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本文引用的文献

1
Normal blood D-dimer concentrations: do they exclude pulmonary embolism?正常的血 D-二聚体浓度:它们能否排除肺栓塞?
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2
The rate of resolution of clot burden measured by pulmonary CT angiography in patients with acute pulmonary embolism.急性肺栓塞患者肺部 CT 血管造影测量的血栓负荷缓解率。
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Diagnosis and management of pulmonary embolism.肺栓塞的诊断与管理
BMJ. 2013 Feb 20;346:f757. doi: 10.1136/bmj.f757.
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Over-reliance of D-dimer in isolation to exclude venous thrombosis should be avoided.应避免单纯过度依赖D-二聚体来排除静脉血栓形成。
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Emergency Department diagnosis of pulmonary embolism is associated with significantly reduced mortality: a linked data population study.急诊科对肺栓塞的诊断与死亡率显著降低相关:一项关联数据人群研究。
Emerg Med Australas. 2009 Aug;21(4):269-76. doi: 10.1111/j.1742-6723.2009.01196.x.
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Pulmonary embolism despite negative ELISA D-dimer: a case report.尽管ELISA D-二聚体检测结果为阴性,但仍发生肺栓塞:一例病例报告。
J Emerg Med. 2009 Oct;37(3):290-2. doi: 10.1016/j.jemermed.2007.11.028. Epub 2008 May 12.
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The absolute risk of venous thrombosis after air travel: a cohort study of 8,755 employees of international organisations.航空旅行后静脉血栓形成的绝对风险:一项对8755名国际组织员工的队列研究。
PLoS Med. 2007 Sep;4(9):e290. doi: 10.1371/journal.pmed.0040290.
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Effectiveness of managing suspected pulmonary embolism using an algorithm combining clinical probability, D-dimer testing, and computed tomography.使用结合临床概率、D-二聚体检测和计算机断层扫描的算法管理疑似肺栓塞的有效性。
JAMA. 2006 Jan 11;295(2):172-9. doi: 10.1001/jama.295.2.172.
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The performance of STA-Liatest D-dimer assay in out-patients with suspected pulmonary embolism.STA-Liatest D-二聚体检测法在疑似肺栓塞门诊患者中的表现。
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