Bruner Vincenzo, Atteno Mariangela, Spanò Angelo, Scarpa Raffaele, Peluso Rosario
Rheumatology Research Unit, Department of Clinical Medicine and Surgery, University Federico II, Naples, Italy.
Rheumatology Research Unit, Department of Clinical Medicine and Surgery, University Federico II, via Sergio Pansini 5, 80131 Naples, Italy.
Ther Adv Musculoskelet Dis. 2014 Jun;6(3):92-101. doi: 10.1177/1759720X14535512.
Biological therapies and new imaging techniques have changed the therapeutic and diagnostic approach to spondyloarthritis. In patients with axial spondyloarthritis, tumor necrosis factor α (TNFα) inhibitor treatment is currently the only effective therapy in patients for whom conventional therapy with nonsteroidal anti-inflammatory drugs (NSAIDs) has failed. TNFα inhibitor treatment is more effective in preventing articular damage in peripheral joints than in axial ones. It is important to treat patients at an early stage of disease to reduce disease progression; moreover it is necessary to identify causes of therapy inefficacy in preventing joint damage in the axial subset.
生物疗法和新的成像技术改变了脊柱关节炎的治疗和诊断方法。在轴性脊柱关节炎患者中,肿瘤坏死因子α(TNFα)抑制剂治疗目前是传统非甾体抗炎药(NSAIDs)治疗失败患者的唯一有效疗法。TNFα抑制剂治疗在预防外周关节的关节损伤方面比在轴性关节更有效。在疾病早期治疗患者以减少疾病进展很重要;此外,有必要确定在预防轴性子集中关节损伤方面治疗无效的原因。