Wong Rebecca S Y
Faculty of Medicine, SEGi University, No. 9, Jalan Teknologi, Taman Sains Selangor, Kota Damansara, PJU 5, 47810 Petaling Jaya, Selangor, Malaysia.
Adv Pharmacol Sci. 2019 Jan 29;2019:5324170. doi: 10.1155/2019/5324170. eCollection 2019.
Spondyloarthritis or spondyloarthropathy (SpA) is a group of related rheumatic disorders, which presents with axial and nonaxial features, affecting structures within the musculoskeletal system, as well as other bodily systems. Both pharmacological and nonpharmacological therapeutic options are available for SpA. For decades, nonsteroidal anti-inflammatory drugs (NSAIDs) have been used as the first-line drugs to treat the disease. Research has shown that other than pain relief, NSAIDs have disease-modifying effects in SpA. However, to achieve these effects, continuous and/or long-term NSAID use is usually required. This review will give an overview of SpA, discuss NSAIDs and their disease-modifying effects in SpA, and highlight some of the important adverse effects of long-term and continuous NSAID use, particularly those related to the gastrointestinal, renal, and cardiovascular systems.
脊柱关节炎或脊柱关节病（SpA）是一组相关的风湿性疾病，表现为轴向和非轴向特征，影响肌肉骨骼系统以及其他身体系统内的结构。SpA有药物和非药物治疗选择。几十年来，非甾体抗炎药（NSAIDs）一直被用作治疗该疾病的一线药物。研究表明，除了缓解疼痛外，NSAIDs在SpA中具有改善病情的作用。然而，要实现这些效果，通常需要持续和/或长期使用NSAIDs。本综述将概述SpA，讨论NSAIDs及其在SpA中的改善病情作用，并强调长期和持续使用NSAIDs的一些重要不良反应，特别是那些与胃肠道、肾脏和心血管系统相关的不良反应。
