长期持续使用非甾体抗炎药（NSAIDs）对脊柱关节炎的病情改善作用
Disease-Modifying Effects of Long-Term and Continuous Use of Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) in Spondyloarthritis.
作者信息
Wong Rebecca S Y
机构信息
Faculty of Medicine, SEGi University, No. 9, Jalan Teknologi, Taman Sains Selangor, Kota Damansara, PJU 5, 47810 Petaling Jaya, Selangor, Malaysia.
出版信息
Adv Pharmacol Sci. 2019 Jan 29;2019:5324170. doi: 10.1155/2019/5324170. eCollection 2019.
Abstract
Spondyloarthritis or spondyloarthropathy (SpA) is a group of related rheumatic disorders, which presents with axial and nonaxial features, affecting structures within the musculoskeletal system, as well as other bodily systems. Both pharmacological and nonpharmacological therapeutic options are available for SpA. For decades, nonsteroidal anti-inflammatory drugs (NSAIDs) have been used as the first-line drugs to treat the disease. Research has shown that other than pain relief, NSAIDs have disease-modifying effects in SpA. However, to achieve these effects, continuous and/or long-term NSAID use is usually required. This review will give an overview of SpA, discuss NSAIDs and their disease-modifying effects in SpA, and highlight some of the important adverse effects of long-term and continuous NSAID use, particularly those related to the gastrointestinal, renal, and cardiovascular systems.
摘要
脊柱关节炎或脊柱关节病（SpA）是一组相关的风湿性疾病，表现为轴向和非轴向特征，影响肌肉骨骼系统以及其他身体系统内的结构。SpA有药物和非药物治疗选择。几十年来，非甾体抗炎药（NSAIDs）一直被用作治疗该疾病的一线药物。研究表明，除了缓解疼痛外，NSAIDs在SpA中具有改善病情的作用。然而，要实现这些效果，通常需要持续和/或长期使用NSAIDs。本综述将概述SpA，讨论NSAIDs及其在SpA中的改善病情作用，并强调长期和持续使用NSAIDs的一些重要不良反应，特别是那些与胃肠道、肾脏和心血管系统相关的不良反应。
相似文献
1
Disease-Modifying Effects of Long-Term and Continuous Use of Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) in Spondyloarthritis.长期持续使用非甾体抗炎药（NSAIDs）对脊柱关节炎的病情改善作用
Adv Pharmacol Sci. 2019 Jan 29;2019:5324170. doi: 10.1155/2019/5324170. eCollection 2019.
2
Brief Report: Six-Week Treatment of Axial Spondyloarthritis Patients With an Optimal Dose of Nonsteroidal Antiinflammatory Drugs: Early Response to Treatment in Signal Intensity on Magnetic Resonance Imaging of the Sacroiliac Joints.简要报告：非甾体抗炎药最佳剂量治疗中轴型脊柱关节炎患者 6 周：骶髂关节磁共振成像信号强度的早期治疗反应。
Arthritis Rheumatol. 2016 Mar;68(3):672-8. doi: 10.1002/art.39474.
3
Effect of non-steroidal anti-inflammatory drugs on radiographic spinal progression in patients with axial spondyloarthritis: results from the German Spondyloarthritis Inception Cohort.非甾体抗炎药对轴性脊柱关节炎患者放射学脊柱进展的影响：来自德国脊柱关节炎起始队列的结果。
Ann Rheum Dis. 2012 Oct;71(10):1616-22. doi: 10.1136/annrheumdis-2011-201252. Epub 2012 Mar 29.
4
Safety of Etoricoxib, Celecoxib, and Nonselective Nonsteroidal Antiinflammatory Drugs in Ankylosing Spondylitis and Other Spondyloarthritis Patients: A Swedish National Population-Based Cohort Study.依托考昔、塞来昔布及非选择性非甾体抗炎药在强直性脊柱炎和其他脊柱关节炎患者中的安全性：一项基于瑞典全国人口的队列研究
Arthritis Care Res (Hoboken). 2015 Aug;67(8):1137-49. doi: 10.1002/acr.22555.
5
Efficacy of long-term nonsteroidal antiinflammatory drug treatment on magnetic resonance imaging-determined bone marrow oedema in early, active axial spondyloarthritis patients.长期使用非甾体类抗炎药治疗对早期活动期轴性脊柱关节炎患者磁共振成像骨髓水肿的疗效。
Clin Rheumatol. 2018 Jan;37(1):245-250. doi: 10.1007/s10067-017-3666-x. Epub 2017 May 11.
6
Pharmacological management of axial spondyloarthritis in adults.成人中轴型脊柱关节炎的药物治疗管理。
Expert Opin Pharmacother. 2019 Aug;20(12):1483-1491. doi: 10.1080/14656566.2019.1617853. Epub 2019 May 16.
7
8
Anti-TNF Therapy in Spondyloarthritis and Related Diseases, Impact on the Immune System and Prediction of Treatment Responses.抗 TNF 治疗在脊柱关节炎及相关疾病中的应用，对免疫系统的影响及治疗反应预测。
Front Immunol. 2019 Mar 19;10:382. doi: 10.3389/fimmu.2019.00382. eCollection 2019.
9
Oral non-steroidal anti-inflammatory drugs versus other oral analgesic agents for acute soft tissue injury.口服非甾体抗炎药与其他口服镇痛药治疗急性软组织损伤的比较
Cochrane Database Syst Rev. 2015 Jul 1(7):CD007789. doi: 10.1002/14651858.CD007789.pub2.
10
A Systematic Review and Meta-analysis Comparing the Efficacy of Nonsteroidal Anti-inflammatory Drugs, Opioids, and Paracetamol in the Treatment of Acute Renal Colic.一种系统评价和荟萃分析比较非甾体抗炎药、阿片类药物和对乙酰氨基酚治疗急性肾绞痛的疗效。
Eur Urol. 2018 Apr;73(4):583-595. doi: 10.1016/j.eururo.2017.11.001. Epub 2017 Nov 22.
引用本文的文献
1
Efficacy and NSAID-sparing effect of secukinumab 150 mg in ankylosing spondylitis: results from phase IV ASTRUM study.司库奇尤单抗150mg治疗强直性脊柱炎的疗效及非甾体抗炎药节省效应：IV期ASTRUM研究结果
Ther Adv Musculoskelet Dis. 2024 Jun 5;16:1759720X241255486. doi: 10.1177/1759720X241255486. eCollection 2024.
2
The modulation effects of the mind-body and physical exercises on the basolateral amygdala-temporal pole pathway on individuals with knee osteoarthritis.身心锻炼对膝骨关节炎患者基底外侧杏仁核-颞极通路的调节作用。
Int J Clin Health Psychol. 2024 Jan-Mar;24(1):100421. doi: 10.1016/j.ijchp.2023.100421. Epub 2023 Nov 22.
3
Frequency and Predictors of Opioid Use in Rheumatoid Arthritis and Seronegative Spondyloarthropathy Patients.类风湿关节炎和血清阴性脊柱关节病患者使用阿片类药物的频率及预测因素
Addict Health. 2022 Oct;14(4):250-255. doi: 10.34172/ahj.2022.1332. Epub 2022 Oct 29.
4
Regenerative Effect of Mesenchymal Stem Cell on Cartilage Damage in a Porcine Model.间充质干细胞对猪模型软骨损伤的再生作用
Biomedicines. 2023 Jun 24;11(7):1810. doi: 10.3390/biomedicines11071810.
5
Therapeutic application of PPE2 protein of Mycobacterium tuberculosis in inhibiting tissue inflammation.结核分枝杆菌 PPE2 蛋白在抑制组织炎症中的治疗应用。
EMBO Mol Med. 2022 Sep 7;14(9):e14891. doi: 10.15252/emmm.202114891. Epub 2022 Jul 11.
6
Nonsteroidal anti-inflammatory drug-sparing effect of secukinumab in patients with radiographic axial spondyloarthritis: 4-year results from the MEASURE 2, 3 and 4 phase III trials.司库奇尤单抗对放射性轴性脊柱关节炎患者的非甾体抗炎药节省效应：MEASURE 2、3和4项III期试验的4年结果
Rheumatol Int. 2022 Feb;42(2):205-213. doi: 10.1007/s00296-021-05044-6. Epub 2021 Nov 13.
7
Targeting Multiple Signal Transduction Pathways of SARS-CoV-2: Approaches to COVID-19 Therapeutic Candidates.靶向 SARS-CoV-2 的多种信号转导通路：COVID-19 治疗候选药物的研究方法。
Molecules. 2021 May 14;26(10):2917. doi: 10.3390/molecules26102917.
8
Role of intracellular signaling pathways and their inhibitors in the treatment of inflammation.细胞内信号通路及其抑制剂在炎症治疗中的作用。
Inflammopharmacology. 2021 Jun;29(3):617-640. doi: 10.1007/s10787-021-00813-y. Epub 2021 May 17.
9
Marham-Mafasel decrease joint inflammation and IL-1β gene expression in rheumatoid arthritis animal model.马哈姆-马法塞尔降低类风湿关节炎动物模型的关节炎症和 IL-1β 基因表达。
Vet Med Sci. 2021 Jul;7(4):1417-1425. doi: 10.1002/vms3.430. Epub 2021 May 3.
10
Non-steroidal anti-inflammatory drugs (NSAIDs) and organ damage: A current perspective.非甾体抗炎药（NSAIDs）与器官损伤：当前观点。
Biochem Pharmacol. 2020 Oct;180:114147. doi: 10.1016/j.bcp.2020.114147. Epub 2020 Jul 10.
本文引用的文献
1
2016 update of the ASAS-EULAR management recommendations for axial spondyloarthritis.2016 年更新的 ASAS-EULAR 中轴型脊柱关节炎管理推荐。
Ann Rheum Dis. 2017 Jun;76(6):978-991. doi: 10.1136/annrheumdis-2016-210770. Epub 2017 Jan 13.
2
Hypersensitivity Reactions to Nonsteroidal Anti-Inflammatory Drugs: An Update.非甾体抗炎药的超敏反应：最新进展
Pharmaceuticals (Basel). 2010 Jan 5;3(1):10-18. doi: 10.3390/ph3010010.
3
Global Prevalence of Spondyloarthritis: A Systematic Review and Meta-Regression Analysis.脊柱关节炎的全球患病率：一项系统评价和Meta回归分析
Arthritis Care Res (Hoboken). 2016 Sep;68(9):1320-31. doi: 10.1002/acr.22831. Epub 2016 Jul 27.
4
Pharmacological treatment of spondyloarthritis: exploring the effectiveness of nonsteroidal anti-inflammatory drugs, traditional disease-modifying antirheumatic drugs and biological therapies.脊柱关节炎的药物治疗：探索非甾体抗炎药、传统改善病情抗风湿药及生物疗法的有效性。
Ther Adv Chronic Dis. 2015 Nov;6(6):328-38. doi: 10.1177/2040622315608647.
5
Predictors of response to TNF antagonists in patients with ankylosing spondylitis and psoriatic arthritis: systematic review and meta-analysis.TNF 拮抗剂治疗强直性脊柱炎和银屑病关节炎患者反应的预测因素：系统评价和荟萃分析。
RMD Open. 2015 Feb 18;1(1):e000017. doi: 10.1136/rmdopen-2014-000017. eCollection 2015.
6
Brief Report: Six-Week Treatment of Axial Spondyloarthritis Patients With an Optimal Dose of Nonsteroidal Antiinflammatory Drugs: Early Response to Treatment in Signal Intensity on Magnetic Resonance Imaging of the Sacroiliac Joints.简要报告：非甾体抗炎药最佳剂量治疗中轴型脊柱关节炎患者 6 周：骶髂关节磁共振成像信号强度的早期治疗反应。
Arthritis Rheumatol. 2016 Mar;68(3):672-8. doi: 10.1002/art.39474.
7
Role of stem cells in spondyloarthritis: Pathogenesis, treatment and complications.干细胞在脊柱关节炎中的作用：发病机制、治疗及并发症
Hum Immunol. 2015 Oct;76(10):781-8. doi: 10.1016/j.humimm.2015.09.038. Epub 2015 Sep 30.
8
Effect of continuous versus on-demand treatment of ankylosing spondylitis with diclofenac over 2 years on radiographic progression of the spine: results from a randomised multicentre trial (ENRADAS).双氯芬酸治疗强直性脊柱炎连续与按需治疗 2 年对脊柱放射学进展的影响：一项随机多中心试验（ENRADAS）的结果。
Ann Rheum Dis. 2016 Aug;75(8):1438-43. doi: 10.1136/annrheumdis-2015-207897. Epub 2015 Aug 4.
9
Serious infection during etanercept, infliximab and adalimumab therapy for rheumatoid arthritis: A literature review.类风湿关节炎患者使用依那西普、英夫利昔单抗和阿达木单抗治疗期间的严重感染：一项文献综述。
Int J Rheum Dis. 2016 Jun;19(6):536-50. doi: 10.1111/1756-185X.12659. Epub 2015 Jul 22.
10
Biological therapies for spondyloarthritis.脊柱关节炎的生物疗法。
Ther Adv Musculoskelet Dis. 2014 Jun;6(3):92-101. doi: 10.1177/1759720X14535512.
Zotero 插件