Department of Pathology, Stony Brook University Medical Center, Stony Brook, NY 11794, USA.
Cytogenetics, Department of Pathology, Stony Brook University Medical Center, Stony Brook, NY 11794, USA.
Biomark Res. 2014 May 9;2:9. doi: 10.1186/2050-7771-2-9. eCollection 2014.
B cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma (DLBCL) and Burkitt's lymphoma (BL) (B-UNC/BL/DLBCL) is a new category of tumors that have features resembling both DLBCL and BL. These tumors have large and medium sized cells with greater irregularity of nuclei and more prominent nucleoli than BL. Approximately 35% to 50% have C-MYC rearrangements, although half are non-immunoglobulin variants. We identified six cases of B-UNC/BL/DLBCL with low-level IGH amplification. Four patients died with a median survival of 7 months (range, 6-20). In conclusion, to our knowledge low-level IGH amplification has not been previously described and should be evaluated for in this patient population.
B 细胞淋巴瘤，分类不明，具有弥漫性大 B 细胞淋巴瘤（DLBCL）和伯基特淋巴瘤（BL）之间的特征（B-UNC/BL/DLBCL）是一种新的肿瘤类别，具有与 DLBCL 和 BL 相似的特征。这些肿瘤具有大细胞和中等大小的细胞，核不规则性较大，核仁较突出，比 BL 更明显。大约 35%至 50%的肿瘤存在 C-MYC 重排，尽管其中一半是非免疫球蛋白变异型。我们发现了 6 例具有低水平 IGH 扩增的 B-UNC/BL/DLBCL。4 名患者死亡，中位生存期为 7 个月（范围为 6-20）。总之，据我们所知，低水平 IGH 扩增以前没有描述过，应该在这一患者群体中进行评估。
