Ohta Takeshi, Katsuda Yoshiaki, Miyajima Katsuhiro, Sasase Tomohiko, Kimura Shuichi, Tong Bin, Yamada Takahisa
Japan Tobacco Inc., Central Pharmaceutical Research Institute, 1-1, Murasaki-cho, Takatsuki, Osaka 569-1125, Japan.
Laboratory of Animal Genetics, Graduate School of Science and Technology, Niigata University, Nishi-ku, Niigata 950-2181, Japan.
J Diabetes Res. 2014;2014:841957. doi: 10.1155/2014/841957. Epub 2014 May 8.
The Spontaneously Diabetic Torii Lepr(fa) (SDT fatty) rat is a novel type 2 diabetic model wherein both male and female rats develop glucose and lipid abnormalities from a young age. In this study, we investigated gender differences in abnormalities and related complications in SDT fatty rats. Food intake was higher in males compared to female rats; however, body weight was not different between genders. Progression of diabetes, including increases in blood glucose and declines in blood insulin, was observed earlier in male rats than in females, and diabetic grade was more critical in male rats. Blood lipids tended to increase in female rats. Gonadal dysfunction was observed in both male and female rats with aging. Microangiopathies, such as nephropathy, retinopathy, neuropathy, and osteoporosis, were seen in both genders, and pathological grade and progression were more significant in males. Qualitative and quantitative changes were observed for metabolic disease gender differences in SDT fatty rats. The SDT fatty rat is a useful model for researching gender differences in metabolic disorders and related diseases in diabetes with obesity.
自发性糖尿病鸟取Lepr(fa)（SDT肥胖）大鼠是一种新型2型糖尿病模型，雌雄大鼠自幼均会出现血糖和脂质异常。在本研究中，我们调查了SDT肥胖大鼠异常及相关并发症的性别差异。雄性大鼠的食物摄入量高于雌性大鼠；然而，两性之间的体重并无差异。糖尿病进展，包括血糖升高和血胰岛素下降，在雄性大鼠中比雌性大鼠出现得更早，且雄性大鼠的糖尿病分级更严重。雌性大鼠的血脂有升高趋势。随着年龄增长，雌雄大鼠均出现性腺功能障碍。微血管病变，如肾病、视网膜病变、神经病变和骨质疏松，在两性中均有出现，且病理分级和进展在雄性中更为显著。在SDT肥胖大鼠中观察到了代谢疾病性别差异的定性和定量变化。SDT肥胖大鼠是研究肥胖型糖尿病代谢紊乱及相关疾病性别差异的有用模型。
