Plasma exchange, methylprednisolone, IV immune globulin, and now anakinra support continued PICU equipoise in management of hyperferritinemia-associated sepsis/multiple organ dysfunction syndrome/macrophage activation syndrome/secondary hemophagocytic lymphohistiocytosis syndrome*.
作者信息
Simon Dennis W, Aneja Rajesh, Carcillo Joseph A, Halstead E Scott
机构信息
Department of Critical Care Medicine and Pediatrics University of Pittsburgh School of Medicine Pittsburgh, PA Department of Pediatrics Pennsylvania State University Hershey, PA.
出版信息
Pediatr Crit Care Med. 2014 Jun;15(5):486-8. doi: 10.1097/PCC.0000000000000098.
Abstract
摘要
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Plasma exchange, methylprednisolone, IV immune globulin, and now anakinra support continued PICU equipoise in management of hyperferritinemia-associated sepsis/multiple organ dysfunction syndrome/macrophage activation syndrome/secondary hemophagocytic lymphohistiocytosis syndrome*.血浆置换、甲泼尼龙、静脉注射免疫球蛋白，以及现在的阿那白滞素，支持在治疗高铁蛋白血症相关的脓毒症/多器官功能障碍综合征/巨噬细胞活化综合征/继发性噬血细胞性淋巴组织细胞增生综合征*时，儿科重症监护室（PICU）持续保持平衡。
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本文引用的文献
1
Therapeutic role of anakinra, an interleukin-1 receptor antagonist, in the management of secondary hemophagocytic lymphohistiocytosis/sepsis/multiple organ dysfunction/macrophage activating syndrome in critically ill children*.阿那白滞素（一种白细胞介素-1受体拮抗剂）在危重症儿童继发性噬血细胞性淋巴组织细胞增生症/脓毒症/多器官功能障碍/巨噬细胞活化综合征治疗中的作用*
Pediatr Crit Care Med. 2014 Jun;15(5):401-8. doi: 10.1097/PCC.0000000000000078.
2
Refractory macrophage activation syndrome in a patient with SLE and APLA syndrome - Successful use of PET- CT and Anakinra in its diagnosis and treatment.系统性红斑狼疮和抗磷脂抗体综合征患者的难治性巨噬细胞活化综合征——正电子发射断层扫描-计算机断层扫描（PET-CT）和阿那白滞素在其诊断和治疗中的成功应用
Mod Rheumatol. 2015;25(6):954-7. doi: 10.3109/14397595.2013.844403. Epub 2013 Oct 21.
3
The hyperferritinemic syndrome: macrophage activation syndrome, Still's disease, septic shock and catastrophic antiphospholipid syndrome.高铁蛋白血症综合征：巨噬细胞活化综合征、斯蒂尔病、感染性休克和灾难性抗磷脂综合征。
BMC Med. 2013 Aug 22;11:185. doi: 10.1186/1741-7015-11-185.
4
Trends in the epidemiology of pediatric severe sepsis*.儿科严重脓毒症的流行病学趋势*。
Pediatr Crit Care Med. 2013 Sep;14(7):686-93. doi: 10.1097/PCC.0b013e3182917fad.
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Reduced frequency of CD56 dim CD16 pos natural killer cells in pediatric systemic inflammatory response syndrome/sepsis patients.儿科全身炎症反应综合征/脓毒症患者中 CD56dimCD16pos 自然杀伤细胞频率降低。
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