脂质乳剂在非局部麻醉药中毒中的应用综述。

Review of the use of lipid emulsion in nonlocal anesthetic poisoning.

作者信息

Kostic Mark A, Gorelick Marc

机构信息

*Associate Medical Director, Wisconsin Poison Center and †Associate Professor of Pediatrics and Emergency Medicine (Kostic); Professor of Pediatric Emergency Medicine (Gorelick), Medical College of Wisconsin, Milwaukee, WI.

出版信息

Pediatr Emerg Care. 2014 Jun;30(6):427-33; quiz 434-6. doi: 10.1097/PEC.0000000000000155.

DOI:10.1097/PEC.0000000000000155

PMID:24892685

Abstract

Intravenous lipid emulsion (ILE) has been used widely for the treatment of poisoning due to local anesthetic agent and is increasingly reported as a therapy for other forms of poisoning. This article will review the proposed mechanisms of action for ILE in poisoning and the evidence from animal studies and human experience supporting the use of ILE for poisoning due to nonlocal anesthetic agents.

摘要

静脉注射脂质乳剂（ILE）已被广泛用于治疗局部麻醉药中毒，并且越来越多地被报道用于治疗其他形式的中毒。本文将综述ILE在中毒治疗中可能的作用机制，以及来自动物研究和人类经验的证据，这些证据支持将ILE用于治疗非局部麻醉药引起的中毒。