Turner-Lawrence Danielle E, Kerns Ii William
Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC, USA.
J Med Toxicol. 2008 Jun;4(2):109-14. doi: 10.1007/BF03160965.
Intravenous fat emulsions (IFE) are traditionally used as a component of parenteral nutrition therapy. Recently, IFE was used to resuscitate severe local anesthetic drug toxicity. This review focuses on the potential role of IFE in treatment of toxicity due to local anesthetics and other lipid-soluble drugs. The general properties of IFE, metabolic fate, and associated adverse events are described. Cases of local anesthetic toxicity treated with IFE are presented along with a discussion of the possible antidotal mechanisms. Initial investigations into the antidotal use of IFE for lipophilic central nervous and cardiovascular drug toxicity are also reviewed.
静脉脂肪乳剂(IFE)传统上用作肠外营养治疗的一个组成部分。最近,IFE被用于抢救严重的局部麻醉药中毒。本综述重点关注IFE在治疗局部麻醉药和其他脂溶性药物中毒方面的潜在作用。描述了IFE的一般特性、代谢转归及相关不良事件。介绍了用IFE治疗局部麻醉药中毒的病例,并讨论了可能的解毒机制。还综述了关于IFE用于亲脂性中枢神经和心血管药物中毒解毒的初步研究。