J Clin Invest. 2014 Jun;124(6):2365-8. doi: 10.1172/JCI75803. Epub 2014 Apr 24.
In this issue of the JCI, Chaurasia and colleagues report an impressive ex vivo expansion of HSCs from human cord blood (CB) using cytokines and altering epigenetic modifications. The application of this protocol provides information that has potential for clinical consideration. The enhanced expansion of CB HSCs is a substantial advance over recent work from the Chaurasia and Hoffman group, in which ex vivo production of human erythroid progenitor cells from CB was promoted by chromatin modification. Moreover, this study takes advantage of information from the rapidly emerging, but not yet fully elucidated, field of epigenetics.
在本期 JCI 中,Chaurasia 及其同事报告了一项令人印象深刻的成果,他们使用细胞因子并改变表观遗传修饰,从人类脐血(CB)中外源扩增造血干细胞(HSCs)。该方案的应用提供了具有临床考虑潜力的信息。与 Chaurasia 和 Hoffman 小组的近期工作相比,该研究在外源扩增 CB HSCs 方面取得了重大进展,他们通过染色质修饰促进了 CB 中人类红系祖细胞的体外生成。此外,该研究还利用了表观遗传学这一快速发展但尚未完全阐明的领域的信息。