用于免疫疾病的蛋白激酶C抑制剂。
Protein kinase C inhibitors for immune disorders.
作者信息
Altman Amnon, Kong Kok-Fai
机构信息
Division of Cell Biology, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA.
Division of Cell Biology, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA.
出版信息
Drug Discov Today. 2014 Aug;19(8):1217-21. doi: 10.1016/j.drudis.2014.05.008. Epub 2014 Jun 2.
Abstract
Protein kinase C (PKC) proteins are a group of well-conserved, intracellular signaling enzymes expressed in all cells and tissues, including immune cells. Much of the molecular insight into PKC immunobiology has been gleaned from studies using PKC gene (Prkc) knockout mice and the analysis of different disease models in these animals. More-recent studies have revealed that PKCs also have crucial roles in the pathogenesis of human immune disorders. Therefore, strategies to modulate the functions of PKC enzymes could have a major impact on the treatment and therapies of autoimmune diseases and other immune disorders.
摘要
蛋白激酶C（PKC）蛋白是一组高度保守的细胞内信号酶，在包括免疫细胞在内的所有细胞和组织中均有表达。对PKC免疫生物学的许多分子认识都来自于使用PKC基因（Prkc）敲除小鼠的研究以及对这些动物不同疾病模型的分析。最近的研究表明，PKC在人类免疫疾病的发病机制中也起着关键作用。因此，调节PKC酶功能的策略可能会对自身免疫性疾病和其他免疫疾病的治疗产生重大影响。
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