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使用具有双或三动脉的活体供肝移植物。

Use of living donor liver grafts with double or triple arteries.

机构信息

1 Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. 2 Address correspondence to: Hideaki Uchiyama, Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu, University, Fukuoka, 812-8582, Japan.

出版信息

Transplantation. 2014 Jun 15;97(11):1172-7. doi: 10.1097/01.TP.0000442687.33536.c4.

DOI:10.1097/01.TP.0000442687.33536.c4
PMID:24892963
Abstract

BACKGROUND

Hepatic grafts used in living donor liver transplantation (LDLT) sometimes have two or more arteries, in which surgeons are required to perform complex arterial reconstruction. The aim of the current study was to demonstrate whether selecting living donor liver grafts with double or triple arteries yielded the same outcomes as grafts with a single artery.

METHODS

We retrospectively investigated the outcomes of LDLT focusing on the numbers of arteries on grafts. Four hundred forty-six cases of LDLT performed between October 1996 and October 2012 were retrospectively analyzed. The cases were divided into the following three groups according to the number of arteries on a graft: the single (n=331), the double (n=108), and the triple (n=7) groups.

RESULTS

Artery-related complications occurred in five cases in the single group, two cases in the double group, and no case in the triple group. Although the overall graft survival was comparable among the three groups, there was a tendency of worsened graft survival and increased incidence of anastomotic biliary stricture after liver transplantation in right hepatic grafts with double arteries.

CONCLUSIONS

The use of grafts with double or triple arteries yielded favorable outcomes with minimum artery-related complications compared with grafts with a single artery. However, the use of right hepatic grafts with double arteries is discouraging in the current study.

摘要

背景

在活体肝移植(LDLT)中使用的肝移植物有时有两条或更多的动脉,这就要求外科医生进行复杂的动脉重建。本研究的目的是证明选择具有双或三动脉的活体供肝移植物与具有单动脉的移植物的结果是否相同。

方法

我们回顾性地研究了 LDLT 的结果,重点关注移植物上的动脉数量。回顾性分析了 1996 年 10 月至 2012 年 10 月期间进行的 446 例 LDLT。根据移植物上的动脉数量将病例分为以下三组:单动脉组(n=331)、双动脉组(n=108)和三动脉组(n=7)。

结果

单动脉组有 5 例发生与动脉相关的并发症,双动脉组有 2 例,三动脉组无病例。尽管三组总体移植物存活率相当,但右肝移植物双动脉组的移植物存活率下降趋势和吻合口胆管狭窄发生率增加。

结论

与单动脉移植物相比,使用双或三动脉移植物可获得良好的结果,并且动脉相关并发症最少。然而,在本研究中,使用双动脉的右肝移植物是令人沮丧的。

相似文献

1
Use of living donor liver grafts with double or triple arteries.使用具有双或三动脉的活体供肝移植物。
Transplantation. 2014 Jun 15;97(11):1172-7. doi: 10.1097/01.TP.0000442687.33536.c4.
2
Extra-anatomical hepatic artery reconstruction in living donor liver transplantation: can this procedure save hepatic grafts?活体肝移植中解剖外肝动脉重建:该手术能否挽救供肝?
Liver Transpl. 2010 Sep;16(9):1054-61. doi: 10.1002/lt.22119.
3
Anatomical and technical aspects of hepatic artery reconstruction in living donor liver transplantation.活体肝移植中肝动脉重建的解剖学与技术方面
Surgery. 2006 Nov;140(5):824-8; discussion 829. doi: 10.1016/j.surg.2006.02.021.
4
Minimizing Hepatic Artery Thrombosis and Establishing Safety of Grafts With Dual Arteries in Living Donor Liver Transplantation.在活体肝移植中减少肝动脉血栓形成并确立双动脉移植物的安全性
Transplant Proc. 2018 Jun;50(5):1378-1385. doi: 10.1016/j.transproceed.2018.02.065.
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Single artery reconstruction in left liver transplantation.左肝移植中单支动脉重建。
Surgery. 2011 Jun;149(6):841-5. doi: 10.1016/j.surg.2010.11.016. Epub 2011 Feb 12.
6
[Hepatic arterial reconstruction and complications management in adult-to-adult living donor liver transplantation].[成人活体肝移植中肝动脉重建及并发症处理]
Zhonghua Wai Ke Za Zhi. 2008 Feb 1;46(3):166-9.
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Branch patch reconstruction in living donor liver transplantation: arterialization of grafts with replaced type arteries.活体肝移植中的分支补片重建:使用替代型动脉进行移植物动脉化
Transplantation. 2006 Dec 15;82(11):1541-3. doi: 10.1097/01.tp.0000236102.36326.a6.
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The use of left grafts with a replaced or accessory left hepatic artery in adult-to-adult living donor liver transplantation: analyses of donor and recipient outcomes.成人对成人活体肝移植中使用带有替代或副左肝动脉的左叶移植物:供体和受体结局分析
Clin Transplant. 2016 Sep;30(9):1021-7. doi: 10.1111/ctr.12783. Epub 2016 Jul 3.
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Cryopreserved arterial grafts as a conduit in outflow reconstruction in living donor liver transplantation.冷冻保存的动脉移植物作为活体供肝移植中流出道重建的管道。
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引用本文的文献

1
Usefulness of microsurgical back-table angioplasty for multiple hepatic arteries in living donor liver transplantation.显微外科手术台上血管成形术在活体肝移植中对多条肝动脉的应用价值
Ann Gastroenterol Surg. 2020 Jul 6;4(6):735-740. doi: 10.1002/ags3.12370. eCollection 2020 Nov.
2
Peritransplant kinetics of Mac-2-binding protein glycosylation isomer levels in living donor liver transplantation: its implication of posttransplant small-for-size syndrome.活体供肝移植中Mac-2结合蛋白糖基化异构体水平的围手术期动力学:其对移植后小肝综合征的意义。
Transl Gastroenterol Hepatol. 2019 May 25;4:41. doi: 10.21037/tgh.2019.05.08. eCollection 2019.